Calvo Veronica, Kenny Paraic A
Breast Cancer Res. 2013 Jan 15;15(1):301. doi: 10.1186/bcr3359.
The local microenvironment influences tumor progression in several important ways. A recent study by Nguyen-Ngoc and colleagues used explants of primary human and mouse mammary tumors to examine how the composition of the extracellular matrix modulates tumor cell invasion. Culture in the presence of a three-dimensional laminin-rich basement membrane, similar to the mammary basement membrane in vivo, resulted in minimal invasion. In contrast, identical tumor fragments in a collagen I matrix which resembles the interstitial breast stroma exhibited a pronounced protrusive migration and local dissemination. These data emphasize the importance of the laminin-rich basement membrane in constraining tumor cell invasion.
局部微环境以多种重要方式影响肿瘤进展。阮玉玉及其同事最近的一项研究使用原发性人类和小鼠乳腺肿瘤的外植体来研究细胞外基质的组成如何调节肿瘤细胞的侵袭。在富含层粘连蛋白的三维基底膜存在下培养，类似于体内乳腺基底膜，导致侵袭最小。相比之下，在类似于乳腺间质基质的I型胶原基质中的相同肿瘤碎片表现出明显的突出迁移和局部扩散。这些数据强调了富含层粘连蛋白的基底膜在限制肿瘤细胞侵袭中的重要性。
