Institute of Animal Nutrition, Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Braunschweig D-38116, Germany.
Toxins (Basel). 2013 Jan 15;5(1):139-61. doi: 10.3390/toxins5010139.
Ergot alkaloids (the sum of individual ergot alkaloids are termed as total alkaloids, TA) are produced by the fungus Claviceps purpurea, which infests cereal grains commonly used as feedstuffs. Ergot alkaloids potentially modulate microsomal and mitochondrial hepatic enzymes. Thus, the aim of the present experiment was to assess their effects on microsomal and mitochondrial liver function using the (13)C-Methacetin (MC) and (13)C-α-ketoisocaproic acid (KICA) breath test, respectively. Two ergot batches were mixed into piglet diets, resulting in 11 and 22 mg (Ergot 5-low and Ergot 5-high), 9 and 14 mg TA/kg (Ergot 15-low and Ergot 15-high) and compared to an ergot-free control group. Feed intake and live weight gain decreased significantly with the TA content (p < 0.001). Feeding the Ergot 5-high diet tended to decrease the 60-min-cumulative (13)CO(2) percentage of the dose recovery (cPDR(60)) by 26% and 28% in the MC and KICA breath test, respectively, compared to the control group (p = 0.065). Therefore, both microsomal and mitochondrial liver function was slightly affected by ergot alkaloids.
麦角生物碱（各种麦角生物碱的总和称为总生物碱，TA）是由麦角菌产生的，它会感染常用作饲料的谷物。麦角生物碱可能会调节微粒体和线粒体肝酶。因此，本实验旨在使用 13C-美沙醋（MC）和 13C-α-酮异己酸（KICA）呼吸试验分别评估它们对微粒体和线粒体肝功能的影响。将两个麦角批次混入仔猪饲料中，导致 TA 含量分别为 11 和 22mg（麦角 5-低和麦角 5-高）和 9 和 14mg/kg（麦角 15-低和麦角 15-高），并与无麦角对照组进行比较。采食量和活体重增重均随 TA 含量显著降低（p<0.001）。与对照组相比，饲喂麦角 5-高日粮时，MC 和 KICA 呼吸试验中的 60 分钟累积（13）CO2 剂量回收百分率（cPDR（60））分别降低了 26%和 28%（p=0.065）。因此，麦角生物碱对微粒体和线粒体肝功能均有轻微影响。
