Cambridge Isotope Laboratories Inc., 50 Frontage Road, Andover, MA 01810, USA.
J Breath Res. 2007 Sep;1(1):014003. doi: 10.1088/1752-7155/1/1/014003. Epub 2007 Jul 11.
Diagnostic (13)C-stable isotope probes are currently being expanded in their scope, to provide precise evaluations of the presence or absence of etiologically significant changes in metabolism due to a specific disease or the lack of a specific enzyme. The salient features of the (13)C-breath test are that they are non-invasive, non-radioactive, safe, simple, and effective. The simplicity of the (13)C-breath test makes it very applicable in a clinical setting: the physician can obtain valuable diagnostic information by distinguishing between two groups or populations on the basis of the recovery of (13)CO(2) from the ingested (13)C-substrate. The breath tests can also be used to monitor the progress of disease severity or to evaluate the efficacy of medications. This review concentrates on current research in the medical field dedicated to the metabolite (13)C-labelled carbon dioxide in exhaled air following ingestion of (13)C-labelled substrates.
诊断用 (13)C-稳定同位素探针目前正在扩大其应用范围，以提供对由于特定疾病或缺乏特定酶而导致的代谢中病因学上有意义的变化的存在或不存在的精确评估。(13)C 呼气试验的显著特点是无创、非放射性、安全、简单和有效。(13)C 呼气试验的简单性使其在临床环境中非常适用：医生可以通过区分两组或两组人群在摄入 (13)C 底物后从 (13)CO(2)的恢复情况来获得有价值的诊断信息。呼气试验还可用于监测疾病严重程度的进展或评估药物的疗效。本综述集中于医学领域中目前关于摄入 (13)C 标记底物后呼出空气中代谢物 (13)C 标记二氧化碳的研究。
