一类新的由γ-谷氨酰转肽酶触发的一氧化氮供体型前药，具有肾选择性血管舒张的潜力。
A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation.
机构信息
University of St Andrews, EaStChem School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife KY16 9ST, UK.
出版信息
Chem Commun (Camb). 2013 Feb 18;49(14):1389-91. doi: 10.1039/c2cc38382a.
Abstract
This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of γ-glutamyl transpeptidase (γ-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).
摘要
本通讯描述了一类新型 N-羟基胍（NHG）前药的合成，这些前药通过 γ-谷氨酰转肽酶（γ-GT）的作用释放一氧化氮（NO），具有治疗急性肾损伤/衰竭（ARI/ARF）的潜力。
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