Tunc Burcu, Gulsoy Murat
Biophotonics Laboratory, Institute of Biomedical Engineering, Bogazici University, Kandilli Kampus, Cengelkoy, 34684 Istanbul, Turkey.
Lasers Surg Med. 2013 Jan;45(1):48-56. doi: 10.1002/lsm.22114. Epub 2013 Jan 15.
The thermal damage of the surrounding tissue can be an unwanted result of continuous-wave laser irradiations. In order to propose an effective alternative to conventional surgical techniques, photothermal damage must be taken under control by a detailed dose study. Real-time temperature monitoring can be also an effective way to get rid of these negative effects. The aim of the present study is to investigate the potential of a new laser-thermoprobe, which consists of a continuous-wave 1,940-nm Tm:fiber laser and a thermocouple measurement system for brain surgery in an ex vivo study.
STUDY DESIGN/MATERIALS AND METHODS: A laser-thermoprobe was designed for using the near-by tissue temperature as a real-time reference for the applicator. Fresh lamb brain tissues were used for experiments. 320 laser shots were performed on both cortical and subcortical tissue.
The relationship between laser parameters, temperature changes, and ablation (removal of tissue) efficiency was determined. The correlation between rate of temperature change and ablation efficiency was calculated.
Laser-thermoprobe leads us to understand the basic laser-tissue interaction mechanism in a very cheap and easy way, without making a change in the experimental design. It was also shown that the ablation and coagulation (thermally irreversible damage) diameters could be predicted, and carbonization can be avoided by temperature monitoring.
连续波激光照射可能会对周围组织造成热损伤，这是一种不良后果。为了提出一种有效的传统手术技术替代方法，必须通过详细的剂量研究来控制光热损伤。实时温度监测也是消除这些负面影响的有效方法。本研究的目的是在一项离体研究中，探究一种新型激光热探针的潜力，该探针由连续波1940纳米铥光纤激光器和用于脑部手术的热电偶测量系统组成。
研究设计/材料与方法：设计了一种激光热探针，将附近组织温度用作施照器的实时参考。使用新鲜羊脑组织进行实验。在皮质和皮质下组织上进行了320次激光照射。
确定了激光参数、温度变化与消融（组织切除）效率之间的关系。计算了温度变化率与消融效率之间的相关性。
激光热探针使我们能够以非常廉价且简便的方式理解基本的激光与组织相互作用机制，而无需改变实验设计。研究还表明，可以预测消融和凝固（热不可逆损伤）直径，并且通过温度监测可以避免碳化。
