Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, MD, USA.
Cancer Epidemiol Biomarkers Prev. 2013 Feb;22(2):181-8. doi: 10.1158/1055-9965.EPI-12-1262. Epub 2013 Jan 15.
Cancer epidemiology is at the cusp of a paradigm shift--propelled by an urgent need to accelerate the pace of translating scientific discoveries into health care and population health benefits. As part of a strategic planning process for cancer epidemiologic research, the Epidemiology and Genomics Research Program (EGRP) at the National Cancer Institute (NCI) is leading a "longitudinal" meeting with members of the research community to engage in an on-going dialogue to help shape and invigorate the field. Here, we review a translational framework influenced by "drivers" that we believe have begun guiding cancer epidemiology toward translation in the past few years and are most likely to drive the field further in the next decade. The drivers include: (i) collaboration and team science, (ii) technology, (iii) multilevel analyses and interventions, and (iv) knowledge integration from basic, clinical, and population sciences. Using the global prevention of cervical cancer as an example of a public health endeavor to anchor the conversation, we discuss how these drivers can guide epidemiology from discovery to population health impact, along the translational research continuum.
癌症流行病学正处于范式转变的边缘——迫切需要加快将科学发现转化为医疗保健和人群健康效益的步伐。作为国家癌症研究所（NCI）癌症流行病学研究战略规划过程的一部分，流行病学和基因组学研究计划（EGRP）正在领导与研究界成员进行一次“纵向”会议，以开展持续对话，帮助塑造和激发该领域。在这里，我们回顾了一个受到“驱动力”影响的转化框架，我们认为这些驱动力在过去几年中开始引导癌症流行病学向转化发展，并且很可能在未来十年进一步推动该领域的发展。这些驱动力包括：（i）合作和团队科学，（ii）技术，（iii）多层次分析和干预，以及（iv）从基础、临床和人群科学中整合知识。我们使用全球预防宫颈癌的努力作为一个公共卫生事业的例子来锚定对话，讨论这些驱动力如何沿着转化研究的连续体引导流行病学从发现到人群健康的影响。
