Mukerjee S, Chander R, Tekwani B L, Gupta S, Katiyar J C, Shukla O P, Kapoor N K
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
Int J Parasitol. 1990 Apr;20(2):217-23. doi: 10.1016/0020-7519(90)90104-u.
An infection of golden hamsters with Ancylostoma ceylanicum, a hookworm parasite, induced profound hyperlipidemia, particularly hypertriglyceridemia, and the effect was directly related to the degree of infection. A significant increase was also noticed in serum cholesterol and phospholipid levels. The appearance of lipoprotein-X, an abnormal low density lipoprotein, was detected in the serum of hookworm-infected animals. The hyperlipidemia was further characterized by an increase in very low density lipoproteins (VLDL) and low density lipoproteins (LDL) with a concomitant decline in high density lipoproteins (HDL). Decreased lipolytic activities, especially triglyceride lipase, in hepatic tissue and induction of lipolytic activities in intestine and adipose tissues indicated mobilization of fats from adipose and jejunum with a defective removal of triglyceride-rich lipoproteins in hepatic tissues. Accumulation of lipids in liver and depletion in adipose tissue supported these results. The derangement may have a significant effect on host parasite interaction and is an important pathophysiological feature occurring during experimental ancylostomiasis.
用锡兰钩虫（一种钩虫寄生虫）感染金黄仓鼠会引发严重的高脂血症，尤其是高甘油三酯血症，且这种效应与感染程度直接相关。血清胆固醇和磷脂水平也显著升高。在感染钩虫的动物血清中检测到异常低密度脂蛋白——脂蛋白-X的出现。高脂血症的进一步特征是极低密度脂蛋白（VLDL）和低密度脂蛋白（LDL）增加，同时高密度脂蛋白（HDL）下降。肝组织中脂解活性降低，尤其是甘油三酯脂肪酶，而肠道和脂肪组织中脂解活性增加，这表明脂肪从脂肪组织和空肠动员起来，但肝组织中富含甘油三酯的脂蛋白清除存在缺陷。肝脏中脂质的积累和脂肪组织中脂质的消耗支持了这些结果。这种紊乱可能对宿主与寄生虫的相互作用产生重大影响，是实验性钩虫病期间出现的一个重要病理生理特征。
