根治性治疗 IV 期胰腺癌的联合冷冻手术和碘 125 种子植入。
Radical treatment of stage IV pancreatic cancer by the combination of cryosurgery and iodine-125 seed implantation.
机构信息
Central Lab of Guangzhou Fuda Cancer Hospital, Guangzhou 510665, Guangdong Province, China.
出版信息
World J Gastroenterol. 2012 Dec 21;18(47):7056-62. doi: 10.3748/wjg.v18.i47.7056.
AIM
To investigate the therapeutic effect of radical treatment and palliative treatment in stage IV pancreatic cancer patients.
METHODS
81 patients were enrolled in the study. Radical treatment was performed on 51 patients, while 30 patients were put under palliative treatment. The procedural safety and interval survival for stage IV pancreatic cancer (IS-IV) was assessed by almost 2.5 years of follow-ups. The IS-IV of patients under the two kinds of treatment, and the effects of treatment timing and frequency on IS-IV, were compared.
RESULTS
The IS-IV of patients who received radical treatment was significantly longer than those who received palliative treatment (P < 0.001). The IS-IV of patients who received delayed radical or palliative treatment was longer than those who received accordingly timely treatment (P = 0.0034 and 0.0415, respectively). Multiple treatments can play an important role in improving the IS-IV of patients who received radical treatment (P = 0.0389), but not for those who received palliative treatment (P = 0.99).
CONCLUSION
The effect of radical treatment was significantly more obvious than that of palliative treatment, and multiple radical treatments may contribute more to patients than a single radical treatment.
目的
探讨晚期胰腺癌患者根治性治疗与姑息性治疗的疗效。
方法
本研究共纳入 81 例患者。51 例患者接受根治性治疗，30 例患者接受姑息性治疗。通过近 2.5 年的随访，评估晚期胰腺癌（IS-IV）患者的程序安全性和间隔生存期（IS-IV）。比较两种治疗方法的 IS-IV，以及治疗时机和频率对 IS-IV 的影响。
结果
接受根治性治疗的患者的 IS-IV 明显长于接受姑息性治疗的患者（P < 0.001）。接受延迟根治性或姑息性治疗的患者的 IS-IV 长于相应及时治疗的患者（P = 0.0034 和 0.0415）。多次治疗可在提高接受根治性治疗患者的 IS-IV 方面发挥重要作用（P = 0.0389），但对接受姑息性治疗的患者则不然（P = 0.99）。
结论
根治性治疗的效果明显优于姑息性治疗，多次根治性治疗可能比单次根治性治疗更有益于患者。
Zotero 插件