Lv Wei-Fu, Lu Dong, Xiao Jing-Kun, Mukhiya Gauri, Tan Zhong-Xiao, Cheng De-Lei, Zhou Chun-Ze, Zhang Xing-Min, Zhang Zheng-Feng, Hou Chang-Long
Department of Interventional Radiology, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China Department of Radiology, BIR Hospital, National Academy of Medical Sciences, Kathmandu, Nepal.
Medicine (Baltimore). 2017 Dec;96(52):e9535. doi: 10.1097/MD.0000000000009535.
The present study investigates the side effects and complications of computed tomography (CT)-guided percutaneous iodine-125 (I-125) seeds implantation for advanced pancreatic cancer.
The clinical data were retrospectively analyzed for patients treated with implantation of I-125 seeds under CT-guide in our hospital from May 2010 to April 2015. The side effects and complications were collected and their possible reasons were analyzed.
A total of 78 patients were enrolled. The side effects were categorized as fever in 29 cases (37.18%), abdominal pain in 26 cases (33.33%), nausea and vomiting in 9 cases (11.54%), diarrhea in 5 cases (6.41%), and constipation in 4 cases (5.13%). Complications were composed of pancreatitis in 9 cases (11.54%), infection in 5 cases (6.41%), seed migration in 2 cases (2.56%), intestinal perforation in 1 case (1.28%), and intestinal obstruction in 1 case. The incidence of complication was 23.08% (18/78). The difference in incidence of complication was statistically significant between patients implanted with ≤27 seeds and those with >27 seeds (P = .032).
The side effects and complications frequently occur in implantation of I-125 seeds for patients with advanced pancreatic cancer. More concern should be given to the patients treated by this technique.
本研究探讨计算机断层扫描（CT）引导下经皮碘-125（I-125）粒子植入治疗晚期胰腺癌的副作用和并发症。
回顾性分析2010年5月至2015年4月在我院接受CT引导下I-125粒子植入治疗患者的临床资料。收集副作用和并发症情况并分析其可能原因。
共纳入78例患者。副作用包括发热29例（37.18%）、腹痛26例（33.33%）、恶心呕吐9例（11.54%）、腹泻5例（6.41%）、便秘4例（5.13%）。并发症包括胰腺炎9例（11.54%）、感染5例（6.41%）、粒子迁移2例（2.56%）、肠穿孔1例（1.28%）、肠梗阻1例。并发症发生率为23.08%（18/78）。植入粒子≤27颗的患者与>27颗的患者并发症发生率差异有统计学意义（P = 0.032）。
晚期胰腺癌患者I-125粒子植入治疗中副作用和并发症频发。应对接受该技术治疗的患者给予更多关注。
