Department of Neurology, Korea University College of Medicine, Seoul, Korea.
J Clin Neurol. 2012 Dec;8(4):276-83. doi: 10.3988/jcn.2012.8.4.276. Epub 2012 Dec 21.
Non-motor symptoms are common in Parkinson's disease (PD), and are the primary cause of disability in many PD patients. Our aim in this study was to translate the origin non-motor symptoms scale for PD (NMSS), which was written in English, into Korean (K-NMSS), and to evaluate its reliability and validity for use with Korean-speaking patients with PD.
In total, 102 patients with PD from 9 movement disorders sections of university teaching hospitals in Korea were enrolled in this study. They were assessed using the K-NMSS, the Unified Parkinson's Disease Rating Scale (UPDRS), the Korean version of the Mini-Mental Status Examination (K-MMSE), the Korean version of the Montgomery-Asberg Depression Rating Scale (K-MADS), the Epworth Sleepiness Scale (ESS), and Parkinson's Disease Questionnaire 39 (PDQ39). Test-retest reliability was assessed over a time interval of 10-14 days in all but one patient.
The K-NMSS was administered to 102 patients with PD. The internal consistency and reliability of this tool was 0.742 (mean Cronbach's α-coefficient). The test-retest correlation reliability was 0.941 (Guttman split-half coefficient). There was a moderate correlation between the total K-NMSS score and the scores for UPDRS part I [Spearman's rank correlation coefficient, (rS)=0.521, p<0.001] and UPDRS part II (rS=0.464, p=0.001), but there was only a weak correlation between the total K-NMSS score and the UPDRS part III score (rS=0.288, p=0.003). The total K-NMSS score was significantly correlated with the K-MADS (rS=0.594, p<0.001), K-MMSE (rS=-0.291, p=0.003), and ESS (rS=0.348, p<0.001). The total K-NMSS score was also significantly and positively correlated with the PDQ39 score (rS=0.814, p<0.001).
The K-NMSS exhibited good reliability and validity for the assessment of non-motor symptoms in Korean PD patients.
非运动症状是帕金森病（PD）的常见症状，也是许多 PD 患者致残的主要原因。本研究旨在将英文版的起源非运动症状量表（NMSS）翻译成韩语（K-NMSS），并评估其在韩国 PD 患者中的信度和效度。
本研究共纳入了韩国 9 家大学附属医院的运动障碍科的 102 名 PD 患者。他们接受了 K-NMSS、统一帕金森病评定量表（UPDRS）、简易精神状态检查量表（K-MMSE）、蒙哥马利-阿斯伯格抑郁评定量表（K-MADS）、Epworth 嗜睡量表（ESS）和帕金森病问卷 39（PDQ39）的评估。除 1 名患者外，其余患者在 10-14 天的时间间隔内进行了两次测试，以评估其重测信度。
102 名 PD 患者接受了 K-NMSS 的评估。该工具的内部一致性和可靠性为 0.742（平均 Cronbach's α 系数）。测试-重测相关性可靠性为 0.941（Guttman 分割半系数）。K-NMSS 总分与 UPDRS 第 I 部分[Spearman 秩相关系数（rS）=0.521，p<0.001]和 UPDRS 第 II 部分（rS=0.464，p=0.001）的评分呈中度相关，但与 UPDRS 第 III 部分的评分仅呈弱相关（rS=0.288，p=0.003）。K-NMSS 总分与 K-MADS（rS=0.594，p<0.001）、K-MMSE（rS=-0.291，p=0.003）和 ESS（rS=0.348，p<0.001）呈显著正相关。K-NMSS 总分与 PDQ39 评分呈显著正相关（rS=0.814，p<0.001）。
K-NMSS 对韩国 PD 患者非运动症状的评估具有良好的信度和效度。
