Zabrodskiĭ P F, Grishin V A
Eksp Klin Farmakol. 2012;75(11):19-21.
It is established in experiments on noninbred rats that the use of imunofan (20 mg/kg daily) and polyoxidonium (150 mg/kg daily) for 7 days on the background of chronic intoxication with organophosphorus agent VX (0.01 LD50, single daily treatment for 30 days) resulted in almost complete recovery of phagocytic-metabolic activity of neutrophils, the content of lysozyme, cationic protein of platelet, and levels of proinflammatory cytokines TNFa, IL-1b and IL-6 in the blood. The administration of T-activin (20 mg/kg daily for 7 days) restores these parameters insignificantly. The maximum overall stimulatory effect was produced by polyoxidonium, while the minimum effect was observed for T-activin.
在非近交系大鼠实验中确定，在有机磷制剂VX慢性中毒（0.01 LD50，每日单次处理30天）背景下，连续7天使用免疫扇（每日20 mg/kg）和聚氧化膦（每日150 mg/kg），可使血液中中性粒细胞的吞噬代谢活性、溶菌酶含量、血小板阳离子蛋白以及促炎细胞因子TNFα、IL-1β和IL-6水平几乎完全恢复。给予T-激活素（每日20 mg/kg，共7天）对这些参数的恢复作用不明显。聚氧化膦产生的总体刺激作用最大，而T-激活素的作用最小。
