Zabrodskiĭ P F, Gromov M S, Iafarova I Kh
Eksp Klin Farmakol. 2013;76(8):35-8.
It has been established in experiments on noninbred rats that chronic intoxication with 1,2-dichloroethane (30 days; total dose 0.9LD50; daily dose 0.03 mg/kg body weight) causes a reduction of immune responses, decreases the activity of acetylcholinesterase (AChE) of T-lymphocytes, reduces the concentration of blood cytokines (IFN-gamma, IL-2, IL-4, IL-6, while not affecting the content of IL-10), and damages to a greater degree Th1 cells as compared to Th2 lymphocytes. The administration of polyoxidonium (daily dose, 150 mg/kg, for 7 days,) partially restored the immune status, the activity of AChE T cells, and the content of cytokines in the blood.
在非近交系大鼠实验中已证实，用1,2 - 二氯乙烷进行慢性中毒（30天；总剂量0.9LD50；每日剂量0.03毫克/千克体重）会导致免疫反应降低，T淋巴细胞乙酰胆碱酯酶（AChE）活性降低，血液细胞因子（IFN - γ、IL - 2、IL - 4、IL - 6，但不影响IL - 10含量）浓度降低，与Th2淋巴细胞相比，Th1细胞受损程度更大。给予聚氧化膦（每日剂量150毫克/千克，共7天）可部分恢复免疫状态、AChE T细胞活性以及血液中细胞因子的含量。
