Liubishin M M, Sivak K V, Savateeva-Liubimova T N
Eksp Klin Farmakol. 2012;75(11):31-4.
The development of delayed disorders caused by acute ethylene glycol poisoning has been studied in experiments on male rats. These disorders include chronic renal failure and secondary combined immunodeficiency status of the "circulus vitiosus" type. Urgent pharmacological correction was shown to be necessary shortly after the poisoning. The experimental therapy (administration of immunomodulators with various mechanisms of action in addition to conventional antidote treatment with ethanol) resulted in the restoration of nonspecific resistance and both cellular and humoral immunity. Reduction of the urinary system damage after the administration of immunomodulators was observed. The results demonstrated the importance of multiagent immunotherapy for the correction of delayed effects of acute ethylene glycol poisoning.
在雄性大鼠实验中研究了急性乙二醇中毒所致迟发性疾病的发展情况。这些疾病包括慢性肾衰竭和“恶性循环”型继发性联合免疫缺陷状态。结果表明，中毒后不久进行紧急药理学纠正很有必要。实验性治疗（除用乙醇进行常规解毒治疗外，给予具有不同作用机制的免疫调节剂）可使非特异性抵抗力以及细胞免疫和体液免疫恢复。观察到给予免疫调节剂后泌尿系统损伤减轻。结果证明了多药联合免疫疗法对纠正急性乙二醇中毒迟发效应的重要性。
