Wang Xiao-hui, Fang Fang, Ding Chang-hong, Lü Jun-lan, Han Tong-li, Liu Li-ying, Li Jiu-wei, Wu Yun, Cui Li-ying, Ren Hai-tao, Xu Chun-ling
Department of Neurology and Rehabilitation, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China.
Zhonghua Er Ke Za Zhi. 2012 Dec;50(12):885-9.
To study the clinical and laboratory features and diagnosis of the patient with anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis in children.
The data of clinical feature, laboratory findings, and radiological manifestation were reviewed and analyzed.
Of the 7 patients, 4 were female and 3 were male. The age of onset was from 6.6 to 15.5 years (average 9.5 years). The onset of 4 cases started with convulsion. Six cases had seizures which was difficult to control by antiepileptic drugs. All patients had psychiatric symptoms and speech disorder. Six cases had different levels of decreased consciousness and dyskinesias. 6 cases had autonomic nerve instability, and 7 cases developed sleep disorders. The results of MRI examination were normal in all patients. The EEG of most patients showed focal or diffuse slow waves. Six cases had oligoclonal bands. All cases were confirmed to have the disease by detection of anti-NMDA receptor antibodies. No tumor was detected in any of the patients. All patients received immunotherapy.
Anti-NMDAR encephalitis is a severe but treatable disorder that frequently affects children and adolescents. Pediatric patients had clinical manifestations similar to those of adult patients. But children have a lower incidence of tumors and hypoventilation also occurs less frequently in children. Most of children had a good prognosis.
研究儿童抗N-甲基-D-天冬氨酸受体（NMDAR）脑炎患者的临床及实验室特征与诊断。
回顾并分析临床特征、实验室检查结果及影像学表现的数据。
7例患者中，4例为女性，3例为男性。发病年龄为6.6至15.5岁（平均9.5岁）。4例以惊厥起病。6例有癫痫发作，抗癫痫药物难以控制。所有患者均有精神症状和言语障碍。6例有不同程度的意识减退和运动障碍。6例有自主神经功能不稳定，7例出现睡眠障碍。所有患者的MRI检查结果均正常。大多数患者的脑电图显示局灶性或弥漫性慢波。6例有寡克隆带。所有病例通过检测抗NMDA受体抗体确诊为此病。所有患者均未检测到肿瘤。所有患者均接受了免疫治疗。
抗NMDAR脑炎是一种严重但可治疗的疾病，常影响儿童和青少年。儿科患者的临床表现与成人患者相似。但儿童肿瘤发生率较低，儿童低通气也较少见。大多数儿童预后良好。
