抗 N-甲基-D-天冬氨酸受体介导的脑炎：儿童诊断与治疗的最新进展

Anti-N-Methyl-D-Aspartate Receptor-Mediated Encephalitis: Recent Advances in Diagnosis and Treatment in Children.

作者信息

Ryan Nicole

机构信息

Division of Neurology, The Children's Hospital of Philadelphia, Philadelphia, PA.

出版信息

Curr Probl Pediatr Adolesc Health Care. 2016 Feb;46(2):58-61. doi: 10.1016/j.cppeds.2015.11.005. Epub 2015 Dec 22.

DOI:10.1016/j.cppeds.2015.11.005

PMID:26705745

Abstract

Anti-N-methyl-d-aspartate receptor-mediated encephalitis (anti-NMDAR encephalitis) is increasingly recognized in children and adolescents. There is a recognizable pattern of clinical symptoms, similar between children and adults. There are some differences in children including the frequency of presenting symptoms, the presence of hypoventilation, and the identification of an associated tumor. Early tumor removal and treatment with immunotherapy is important for rapid recovery. The prognosis can be surprisingly good but some children have lasting neurocognitive deficits.

摘要

抗 N-甲基-D-天冬氨酸受体介导的脑炎（抗 NMDAR 脑炎）在儿童和青少年中越来越受到关注。其临床症状具有可识别的模式，儿童和成人相似。儿童存在一些差异，包括症状出现的频率、通气不足的情况以及相关肿瘤的识别。早期切除肿瘤并进行免疫治疗对快速康复很重要。预后可能出奇地好，但一些儿童会有持续的神经认知缺陷。