Takano Tamaki, Terasaki Takamitsu, Wada Yuko, Ohashi Noburou, Komatsu Kazunori, Fukui Daisuke, Amano Jun
Department of Cardiovascular Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.
J Cardiothorac Surg. 2013 Jan 16;8:11. doi: 10.1186/1749-8090-8-11.
We report a case of early bioprosthetic valve calcification in a 76 year-old woman who had received supplementation with alfacalcidol, an analogue of vitamin D, for 3 years after her initial valve replacement. She underwent aortic valve replacement at the age of 71 and subsequently complained of shortness of breath. Ultrasonic cardiography revealed severe aortic stenosis and we performed a second aortic valve replacement with a bioprosthesis. Histopathologic and x-ray examination showed calcification on the explanted valve. She had not presented with any known risk for early bioprosthetic calcification, suggesting that vitamin D supplementation may accelerate calcification of bioprosthetic valves.
我们报告一例76岁女性早期生物瓣膜钙化的病例，该患者在首次瓣膜置换术后接受维生素D类似物阿法骨化醇补充治疗3年。她71岁时接受了主动脉瓣置换术，随后出现气短症状。超声心动图显示严重主动脉瓣狭窄，我们为其进行了第二次生物瓣膜主动脉瓣置换术。组织病理学和X线检查显示取出的瓣膜有钙化。她没有出现任何已知的早期生物瓣膜钙化风险因素，提示补充维生素D可能会加速生物瓣膜的钙化。
