Williams E H, Gonti V R, Nishimura A, Stout L C, Ferrans V
J Thorac Cardiovasc Surg. 1981 Sep;82(3):391-7.
The clinical course of a patient with bioprosthetic failure of aortic and mitral Ionescu-Shiley valves (which contain bovine pericardial leaflets) is presented. Failure occurred in less than 4 months and was due to infection that resulted in calcification and severe stenosis. On examination of tissue specimens under light and electron microscopes, the pathological process was seen to be similar o that occurring with infected porcine prostheses.
本文介绍了一名主动脉和二尖瓣Ionescu-Shiley生物瓣膜（含牛心包瓣叶）出现生物假体功能衰竭患者的临床病程。功能衰竭发生在不到4个月的时间内，原因是感染导致钙化和严重狭窄。在光学显微镜和电子显微镜下检查组织标本时，发现病理过程与感染猪生物假体时发生的过程相似。
