Laboratory of Genetics, Immunology and Human Pathology, Department of Biology, Faculty of Sciences of Tunis, Tunis, Tunisia.
Dis Markers. 2013;34(2):63-9. doi: 10.3233/DMA-120947.
Aurora A kinase is overexpressed in many cancers but the status of this protein in the breast cancer often varies. We investigate the expression and localization of Aurora A protein in relation with tumor emergence and progression in breast cancer. Aurora A kinase status was evaluated in 107 patients using immunohistochemistry. The experimental findings showed that high expression of the Aurora A protein was correlated with elevated nuclear grade, low expression of progesterone receptor and positive nodal status. The experimental results showed also that the localization of this kinase shifts from cytoplasm in non malignant adjacent tissue to both cytoplasmic and nuclear compartments in tumoral tissue, suggesting an oncogenic role of the nuclear accumulation. We have, furthermore, detected the overexpression of this protein in non malignant adjacent tissue. The expression of the Aurora A kinase in non malignant tissue may represent an earlier diagnosis tool for breast cancer.
极光激酶 A 在许多癌症中过度表达，但在乳腺癌中这种蛋白质的状态常常不同。我们研究了极光激酶 A 蛋白在乳腺癌发生和进展中的表达和定位。使用免疫组织化学方法评估了 107 例患者的极光激酶 A 状态。实验结果表明，极光 A 蛋白的高表达与核级升高、孕激素受体低表达和淋巴结阳性相关。实验结果还表明，这种激酶的定位从非恶性相邻组织的细胞质转移到肿瘤组织的细胞质和核区室，提示核聚集具有致癌作用。此外，我们还在非恶性相邻组织中检测到这种蛋白的过度表达。非恶性组织中极光 A 激酶的表达可能是乳腺癌的早期诊断工具。
