WHO HPV LabNet Global Reference Laboratory, Department of Clinical Microbiology, University and Regional Laboratories Region Skåne, Malmö, Sweden.
Sex Transm Dis. 2013 Feb;40(2):123-9. doi: 10.1097/OLQ.0b013e31827aa9b3.
Monitoring of condylomas is an early evidence of population effectiveness of human papillomavirus (HPV) vaccination programs. If reporting could include HPV typing, the contribution by vaccine HPV types to condyloma burden could be monitored.
A sentinel site for reporting of condyloma including HPV typing was established at the Centre for Sexual Health in Malmö, Sweden. In 2006 to 2009, when there were few HPV vaccines, 621 subjects with condyloma were reported and HPV genotyped.
Ninety-four percent of the condylomas contained genital HPV types. Thirty-five different genital HPV types were identified, with HPV6 (62%), HPV16 (13%), and HPV11 (10%) being the most common. At least 1 of the 4 HPV types in the HPV6/11/16/18 vaccine was detected in 77%. High-risk HPV types were more common in females (45%) than among males (27%) (odds ratio, 1.9; confidence interval, 1.3-2.8). Extended testing among subjects initially negative for HPV found 21 patients with cutaneous types of HPV, including a novel type (HPV153).
This report provides a baseline distribution of HPV types in condylomas before the introduction of an HPV vaccination program in this population. Human papillomavirus typing is feasible in routine condyloma reporting.
监测尖锐湿疣是评估人乳头瘤病毒（HPV）疫苗接种计划对人群效果的早期证据。如果报告中包括 HPV 型别，就可以监测疫苗 HPV 型别对尖锐湿疣负担的贡献。
在瑞典马尔默性健康中心建立了一个报告尖锐湿疣（包括 HPV 型别）的哨点。在 2006 年至 2009 年 HPV 疫苗较少的时期，报告并 HPV 基因分型了 621 例尖锐湿疣患者。
94%的尖锐湿疣含有生殖器 HPV 型别。共鉴定出 35 种不同的生殖器 HPV 型别，HPV6（62%）、HPV16（13%）和 HPV11（10%）最为常见。至少 1 种 HPV6/11/16/18 疫苗包含的 4 种 HPV 型别在 77%的患者中被检测到。高危型 HPV 在女性（45%）中比男性（27%）更常见（比值比，1.9；95%置信区间，1.3-2.8）。对最初 HPV 阴性的患者进行扩展检测，发现 21 例患者携带 HPV 皮肤型，包括一种新型 HPV153。
本报告提供了该人群在 HPV 疫苗接种计划引入之前尖锐湿疣 HPV 型别的基线分布情况。HPV 型别检测在常规尖锐湿疣报告中是可行的。
