Miami Transplant Institute, Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
Transplantation. 2013 Jan 27;95(2):309-18. doi: 10.1097/TP.0b013e31827191d4.
Although a longer time on dialysis before kidney transplant waitlisting has been shown for Blacks versus non-Blacks, relatively few studies have compared this outcome between Hispanics and Whites.
A multivariable analysis of 1910 (684 Black, 452 Hispanic, and 774 White) consecutive patients waitlisted at our center for a primary kidney transplant between 2005 and mid-2010 was performed for time from starting dialysis to waitlisting (months), the percentage who were preemptively waitlisted (waitlisted before starting dialysis), and time from starting dialysis to waitlisting after excluding the preemptively waitlisted patients.
The variables associated with significantly longer median times from starting dialysis to waitlisting and less preemptive waitlisting included Medicare insurance for patients ages <65 years (by far, the most significant variable in each analysis), Black race, higher percentage of households in the patient's zip code living in poverty, being a non-U.S. citizen (for preemptive waitlisting), Medicaid insurance, waitlisted for kidney-alone (vs. kidney-pancreas) transplant, and higher body mass index (longer median times for the latter three variables). Although the effect of Black race was mostly explained by significant associations with lower socioeconomic status (Medicare insurance for patients ages <65 years and greater poverty in the patient's zip code), an unexplained component still remained. The univariable differences showing poorer outcomes for Hispanics versus Whites were smaller and completely explained in multivariable analysis by significant associations with lower socioeconomic status and non-U.S. citizenship.
Black and Hispanic patients had significantly longer times from starting dialysis to waitlisting, in large part related to their lower socioeconomic status and less preemptive waitlisting. A greater focus on earlier nephrology care may help to erase much of these disparities.
尽管与非黑人相比,黑人在等待肾移植期间接受透析的时间更长,但相对较少的研究比较了西班牙裔和白人之间的这种结果。
对 2005 年至 2010 年年中在我们中心等待首次肾移植的 1910 名(684 名黑人、452 名西班牙裔和 774 名白人)连续患者进行了多变量分析,以评估从开始透析到等待名单的时间(月)、预先等待名单的百分比(在开始透析之前等待名单)以及排除预先等待名单患者后从开始透析到等待名单的时间。
与从开始透析到等待名单的中位数时间显著延长和预先等待名单比例较低相关的变量包括<65 岁患者的医疗保险(在每项分析中都是迄今为止最重要的变量)、黑种人、患者邮政编码中生活贫困的家庭比例较高、非美国公民(预先等待名单)、医疗补助保险、单独等待肾脏(与肾脏-胰腺)移植、以及更高的身体质量指数(后三个变量的中位数时间较长)。尽管黑种人种族的影响主要归因于与较低社会经济地位(<65 岁患者的医疗保险和患者邮政编码中的贫困程度较高)的显著关联,但仍存在未解释的部分。西班牙裔与白人相比结果较差的单变量差异在多变量分析中较小,并且完全由与较低社会经济地位和非美国公民身份的显著关联所解释。
黑人和西班牙裔患者从开始透析到等待名单的时间明显更长,这在很大程度上与他们较低的社会经济地位和较少的预先等待名单有关。更加关注早期肾脏病护理可能有助于消除这些差异中的大部分。