镍催化的氧杂双环烯烃与炔烃和硼酸酯的区域和立体选择性的分子间三组分偶联反应。
Nickel-catalyzed regio- and diastereoselective intermolecular three-component coupling of oxabicyclic alkenes with alkynes and organoboronic acids.
机构信息
Department of Chemistry, National Tsing Hua University, Hsinchu 30043, Taiwan.
出版信息
Chem Commun (Camb). 2013 Feb 21;49(15):1557-9. doi: 10.1039/c2cc38001c.
PMID:23325053
Abstract
Reaction of oxabicyclic alkenes with alkynes and organoboronic acids in the presence of Ni(cod)(2), P(t-Bu)(3), and CsF in a binary solvent toluene-methanol (1 : 3) at 75 to 85 °C provided exo-5,6-disubstituted 7-oxanorbornene derivatives in good to excellent yields.
摘要
在 75 至 85°C 下，在 Ni(cod)(2)、P(t-Bu)(3)和 CsF 的存在下，在甲苯-甲醇（1:3）的二元溶剂中，氧杂双环烯烃与炔烃和有机硼酸反应，以良好至优异的收率提供了外消旋的 5,6-二取代的 7-氧杂降冰片烯衍生物。
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