镍催化的通过磺酰基自由基的炔烃的分子间碳磺酰化反应。
Nickel-Catalyzed Intermolecular Carbosulfonylation of Alkynes via Sulfonyl Radicals.
机构信息
Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
出版信息
Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9949-9952. doi: 10.1002/anie.201704862. Epub 2017 Jul 17.
PMID:28715151
Abstract
β,β-Disubstituted vinyl sulfones were obtained with complete regio- and stereocontrol in a multicomponent reaction involving alkynes, organoboronic acids, and sulfonyl chlorides in the presence of a nickel catalyst. The reaction proceeds via sulfonyl radicals generated in situ under mild reaction conditions.
摘要
β,β-二取代乙烯砜在多组分反应中以完全区域和立体选择性得到，该反应涉及炔烃、硼酸酯和亚磺酰氯，在镍催化剂的存在下进行。反应在温和的反应条件下通过原位生成的亚磺酰基自由基进行。
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