Department of Neurology, University of Maryland Medical Center, 22 South Green Street, Baltimore, MD, 21201, USA,
Curr Treat Options Neurol. 2013 Apr;15(2):125-49. doi: 10.1007/s11940-012-0217-2.
Hemorrhagic Transformation (HT) has been well recognized as a common cause of hemorrhage in ischemic stroke patients. Though this complication may occur independently, it has been particularly dreaded in the post rTPA patient and thus has been the focus for analysis of multiple thrombolytic trials. This review examines the effect of different clinical predictors for hemorrhagic transformation and summarizes pertinent clinical trials, with a focus on the rational for design of future studies. Although currently there are no official guidelines for the acute management of HT per se, based upon review of the literature regarding pertinent clinical predictors herein, an innovative approach for the acute management of the HT patient is proposed.
出血转化（HT）已被公认为缺血性脑卒中患者出血的常见原因。尽管这种并发症可能独立发生，但在 rTPA 后患者中尤其令人恐惧，因此一直是多个溶栓试验分析的重点。本综述考察了不同临床预测因子对出血转化的影响，并总结了相关的临床试验，重点探讨了未来研究设计的合理性。虽然目前尚无针对 HT 本身的急性治疗的官方指南，但基于本文中有关相关临床预测因子的文献复习，提出了一种针对 HT 患者的急性治疗的创新方法。
