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[患有慢性获得性心脏瓣膜病的“无症状”患者]

[The "asymptomatic" patient with chronic acquired heart valve disease].

作者信息

Horstkotte D, Prinz C, Piper C

机构信息

Kardiologische Klinik, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Bad Oeynhausen, Deutschland.

出版信息

Internist (Berl). 2013 Jan;54(1):7-8, 10, 12-4, 16-7. doi: 10.1007/s00108-012-3092-8.

Abstract

An intervention for chronic acquired valvular heart disease may either be indicated in symptomatic patients to relieve symptoms and improve quality of life or in asymptomatic patients to improve long-term prognosis, e.g., by preventing disease-related complications like chronic heart failure or arrhythmias. For proper action according to current guidelines, the systematic evaluation of symptoms related to the underlying valve disease is of utmost importance. If a discrepancy between symptoms reported or not reported by the patients and the severity of the valve disease is supposed, true absence of symptoms and exercise tolerance should be verified by spiroergometry. In the truly asymptomatic patient with a severe valvular lesion, preservation of myocardial adaption to the chronic volume or pressure overload should be tested utilizing appropriate imaging techniques like radionuclide ventriculography under exercise conditions. The proper evaluation of the functional status is of growing importance in our aging population with its sedentary lifestyle. In this context, the results of a survey should be kept in mind, which indicated that a significant proportion of patients still have interventions too late during the natural history of their valve disease with symptoms of congestive heart failure, arrhythmias, and the risk of sudden cardiac death persisting after a primarily successful valve repair or replacement.

摘要

对于慢性获得性瓣膜性心脏病的干预,可能适用于有症状的患者以缓解症状并改善生活质量,或适用于无症状的患者以改善长期预后,例如通过预防与疾病相关的并发症,如慢性心力衰竭或心律失常。为了根据当前指南采取适当行动,对与潜在瓣膜疾病相关的症状进行系统评估至关重要。如果怀疑患者报告或未报告的症状与瓣膜疾病的严重程度之间存在差异,则应通过运动心肺功能测试来验证真正无症状和运动耐量情况。对于患有严重瓣膜病变的真正无症状患者,应利用适当的成像技术,如运动条件下的放射性核素心室造影,来测试心肌对慢性容量或压力超负荷的适应性保留情况。在我们这个久坐不动生活方式的老龄化人口中,对功能状态的正确评估变得越来越重要。在这种情况下,应牢记一项调查结果,该调查表明,相当一部分患者在瓣膜疾病自然史期间进行干预仍然过晚,在首次成功进行瓣膜修复或置换后,充血性心力衰竭、心律失常症状以及心源性猝死风险仍然存在。

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