Department of Infectious Diseases and Clinical Microbiology, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey.
Eur J Gastroenterol Hepatol. 2013 May;25(5):606-12. doi: 10.1097/MEG.0b013e32835d08da.
We aimed to determine whether mean platelet volume (MPV) is one of the variables that determine the severity of liver fibrosis and inflammation.
Patients with chronic hepatitis B virus (HBV) infection were divided into two groups: patients with fibrosis scores of 0-3 and 4-6 and patients with histologic activity index scores of 0-9 and 10-18 (according to the Ishak Scoring System). The independent variables determining the severity of liver fibrosis and inflammation were investigated.
Two hundred and thirty-eight patients were included in this retrospective study. The fibrosis scores of 29 patients (12.2%) were higher than 3. The independent variables that determined the severity of the fibrosis score were a high level of serum γ-glutamyl transferase and a low blood platelet count (odds ratio and P values were 1.016 and 0.004 for γ-glutamyl transferase, and 0.986 and 0.002 for blood platelet count). The histologic activity indexes of 38 patients (16%) were higher than 9. The independent variables determining the severity of liver inflammation were serum HBV DNA, γ-glutamyl transferase, and globulin levels and the MPV [odds ratio and P values were, respectively, 0.1001 and 0.046 for HBV DNA (×10); 1.016 and 0.004 for γ-glutamyl transferase; 2.247 and 0.039 for globulin; and 1.488 and 0.004 for the MPV]. The sensitivity, specificity, and positive predictive value and negative predictive value of the model predicting the severity of liver inflammation were 60.5, 83, 40.3, and 91.7%, respectively (area under the receiver-operating characteristic curve=0.775, P=0.0001).
MPV may provide useful information to predict the degree of liver inflammation along with other markers.
我们旨在确定平均血小板体积（MPV）是否是决定肝纤维化和炎症严重程度的变量之一。
将慢性乙型肝炎病毒（HBV）感染患者分为两组：纤维化评分 0-3 分和 4-6 分的患者，以及组织学活动指数评分 0-9 分和 10-18 分的患者（根据 Ishak 评分系统）。研究了确定肝纤维化和炎症严重程度的独立变量。
本回顾性研究纳入了 238 例患者。29 例（12.2%）患者的纤维化评分较高，为 3 分以上。决定纤维化评分严重程度的独立变量是血清γ-谷氨酰转移酶水平升高和血小板计数降低（γ-谷氨酰转移酶的比值比和 P 值分别为 1.016 和 0.004，血小板计数的比值比和 P 值分别为 0.986 和 0.002）。38 例（16%）患者的组织学活动指数较高，为 9 分以上。决定肝炎症严重程度的独立变量是血清 HBV DNA、γ-谷氨酰转移酶和球蛋白水平以及 MPV[比值比和 P 值分别为 HBV DNA（×10）的 0.1001 和 0.046；γ-谷氨酰转移酶的 1.016 和 0.004；球蛋白的 2.247 和 0.039；MPV 的 1.488 和 0.004]。预测肝炎症严重程度的模型的灵敏度、特异度、阳性预测值和阴性预测值分别为 60.5%、83%、40.3%和 91.7%（受试者工作特征曲线下面积=0.775，P=0.0001）。
MPV 可能与其他标志物一起提供预测肝炎症程度的有用信息。
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