慢性乙型肝炎感染患者血小板参数与肝脏病理的关系——一项对677例患者的回顾性队列研究
Relationship between platelet parameters and hepatic pathology in patients with chronic hepatitis B infection - a retrospective cohort study of 677 patients.
作者信息
Pan Ye, Muheremu Aikeremujiang, Wu Xiaolu, Liu Jiajun
机构信息
Department of Infectious Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Sixth affiliated hospital of Xinjiang Medical University, Xinjiang, China
出版信息
J Int Med Res. 2016 Aug;44(4):779-86. doi: 10.1177/0300060516650076. Epub 2016 Jun 21.
OBJECTIVE
A retrospective study to determine the relationships between platelet parameters and inflammation and fibrosis of the liver in patients with chronic hepatitis B virus infection (CHB).
METHODS
Patients with liver biopsy-confirmed CHB were included in the study. Liver fibrosis and inflammation were assessed by histopathology of biopsied liver tissue. Platelet count (PLT), platelet distribution width (PDW) and mean platelet volume (MPV) were determined as part of routine blood tests. The relationship between inflammation and fibrosis and platelet parameters were analysed by multiple linear regression.
RESULTS
The study included 677 patients. PLT and PDW accounted for 20.5% of liver inflammation. PLT and PDW accounted for 18.4% of liver fibrosis.
CONCLUSION
Platelet parameters can provide valuable information for the assessment of hepatic inflammation and fibrosis.
目的
进行一项回顾性研究，以确定慢性乙型肝炎病毒感染（CHB）患者血小板参数与肝脏炎症和纤维化之间的关系。
方法
纳入经肝活检确诊为CHB的患者。通过对活检肝组织进行组织病理学评估肝脏纤维化和炎症。血小板计数（PLT）、血小板分布宽度（PDW）和平均血小板体积（MPV）作为常规血液检查的一部分进行测定。通过多元线性回归分析炎症、纤维化与血小板参数之间的关系。
结果
该研究纳入了677例患者。PLT和PDW占肝脏炎症的20.5%。PLT和PDW占肝脏纤维化的18.4%。
结论
血小板参数可为评估肝脏炎症和纤维化提供有价值的信息。
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