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本文引用的文献

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Structure-activity relationships of saponin derivatives: a series of entry inhibitors for highly pathogenic H5N1 influenza virus.皂甙衍生物的构效关系：高致病性 H5N1 流感病毒的一系列进入抑制剂。
Eur J Med Chem. 2012 Jul;53:316-26. doi: 10.1016/j.ejmech.2012.04.022. Epub 2012 Apr 21.
2
Prospective of Genomics in Revealing Transmission, Reassortment and Evolution of Wildlife-Borne Avian Influenza A (H5N1) Viruses.基因组学在揭示野生动物源甲型 H5N1 禽流感病毒传播、重配和进化中的前景。
Curr Genomics. 2011 Nov;12(7):466-74. doi: 10.2174/138920211797904052.
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Inhibition of autophagy ameliorates acute lung injury caused by avian influenza A H5N1 infection.自噬抑制可改善甲型 H5N1 禽流感病毒感染引起的急性肺损伤。
Sci Signal. 2012 Feb 21;5(212):ra16. doi: 10.1126/scisignal.2001931.
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Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling.甲型流感病毒通过环氧化酶-2 和蛋白激酶 A 信号诱导白细胞介素-27 的产生。
J Biol Chem. 2012 Apr 6;287(15):11899-910. doi: 10.1074/jbc.M111.308064. Epub 2012 Feb 16.
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Interferon dysregulation and virus-induced cell death in avian influenza H5N1 virus infections.禽流感 H5N1 病毒感染中的干扰素失调和病毒诱导的细胞死亡。
Hong Kong Med J. 2012 Feb;18 Suppl 2:12-6.
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Induction of heterosubtypic cross-protection against influenza by a whole inactivated virus vaccine: the role of viral membrane fusion activity.诱导针对流感的异亚型交叉保护作用的全灭活病毒疫苗：病毒膜融合活性的作用。
PLoS One. 2012;7(1):e30898. doi: 10.1371/journal.pone.0030898. Epub 2012 Jan 27.
7
Newly established monoclonal antibodies for immunological detection of H5N1 influenza virus.用于免疫检测 H5N1 流感病毒的新建立的单克隆抗体。
Jpn J Infect Dis. 2012;65(1):19-27.
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Polyvalent DNA vaccines expressing HA antigens of H5N1 influenza viruses with an optimized leader sequence elicit cross-protective antibody responses.多价 DNA 疫苗表达具有优化的前导序列的 H5N1 流感病毒的 HA 抗原，可引起交叉保护抗体反应。
PLoS One. 2011;6(12):e28757. doi: 10.1371/journal.pone.0028757. Epub 2011 Dec 21.
9
Eurasian Tree Sparrows, risk for H5N1 virus spread and human contamination through Buddhist ritual: an experimental approach.欧亚树麻雀，H5N1 病毒传播风险及通过佛教仪式污染人类：实验方法。
PLoS One. 2011;6(12):e28609. doi: 10.1371/journal.pone.0028609. Epub 2011 Dec 2.
10
A human monoclonal antibody with neutralizing activity against highly divergent influenza subtypes.一种具有中和活性的针对高度分化流感亚型的人源单克隆抗体。
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高致病性 H5N1 流感病毒概述。

An overview of the highly pathogenic H5N1 influenza virus.

机构信息

The State Key laboratory of Virology and College of Life Sciences, Wuhan University, Wuhan 430072, China.

出版信息

Virol Sin. 2013 Feb;28(1):3-15. doi: 10.1007/s12250-013-3294-9. Epub 2013 Jan 16.

DOI:10.1007/s12250-013-3294-9
PMID:23325419
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7090813/
Abstract

Since the first human case of H5N1 avian influenza virus infection was reported in 1997, this highly pathogenic virus has infected hundreds of people around the world and resulted in many deaths. The ability of H5N1 to cross species boundaries, and the presence of polymorphisms that enhance virulence, present challenges to developing clear strategies to prevent the pandemic spread of this highly pathogenic avian influenza (HPAI) virus. This review summarizes the current understanding of, and recent research on, the avian influenza H5N1 virus, including transmission, virulence, pathogenesis, clinical characteristics, treatment and prevention.

摘要

自 1997 年首次报告人类感染 H5N1 禽流感病毒以来，这种高致病性病毒已感染了全球数百人，并导致许多人死亡。H5N1 能够跨越物种界限，并且存在增强毒力的多态性，这给制定明确的策略来防止这种高致病性禽流感（HPAI）病毒的大流行传播带来了挑战。本文综述了目前对禽流感 H5N1 病毒的认识和最新研究，包括传播、毒力、发病机制、临床特征、治疗和预防。