熊去氧胆酸及其牛磺酸共轭物对大鼠磺溴酞钠胆汁排泄影响的差异。

Difference in the effects of ursodeoxycholate and its taurine conjugate on the biliary excretion of sulfobromophthalein in the rat.

作者信息

Kanai S, Kitani K, Sato Y

机构信息

First Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.

出版信息

J Hepatol. 1990 Mar;10(2):174-9. doi: 10.1016/0168-8278(90)90048-v.

DOI:10.1016/0168-8278(90)90048-v

PMID:2332588

Abstract

A simultaneous intravenous infusion of sulfobromophthalein (BSP) (0.3 mg.min-1.100 g-1) and ursodeoxycholate (UDC) or tauroursodeoxycholate (TUDC) (1.2 mumol.min-1.100 g-1) caused a significantly higher excretion rate of BSP than in the control value without bile salt infusion. In UDC-infused rats, however, the BSP excretion rate began to fall rapidly within the first 30 min of infusion, while the bile flow rate remained high, or even continued to increase. In contrast, the BSP excretion rate in TUDC-infused rats was stable up to 60 min and then began to decline in parallel with the fall of bile flow rate. A significant increase in the BSP transport maximum (Tm) induced by UDC and TUDC in rats does not agree with a previous observation in hamsters where neither of these bile salts enhanced BSP Tm. The discrepancy between these two studies can best be explained by the poor biliary excretion of either TUDC or UDC in hamsters as was previously reported. It was concluded that in rats both TUDC and UDC can significantly increase BSP Tm, which paralleled the excretion rate of bile salts and not the bile flow rate.

摘要

同时静脉输注磺溴酞钠（BSP）（0.3毫克·分钟⁻¹·100克⁻¹）和熊去氧胆酸（UDC）或牛磺熊去氧胆酸（TUDC）（1.2微摩尔·分钟⁻¹·100克⁻¹）导致BSP的排泄率显著高于未输注胆盐时的对照值。然而，在输注UDC的大鼠中，BSP排泄率在输注的前30分钟内开始迅速下降，而胆汁流速仍保持较高水平，甚至继续增加。相比之下，输注TUDC的大鼠中BSP排泄率在60分钟内保持稳定，然后随着胆汁流速的下降而开始下降。UDC和TUDC在大鼠中诱导的BSP转运最大值（Tm）显著增加，这与之前在仓鼠中的观察结果不一致，在仓鼠中这两种胆盐均未提高BSP的Tm。正如之前所报道的，这两项研究之间的差异最好用仓鼠中TUDC或UDC较差的胆汁排泄来解释。得出的结论是，在大鼠中，TUDC和UDC均可显著增加BSP的Tm，这与胆盐的排泄率而非胆汁流速平行。