Delage Y, Dumont M, Erlinger S
Gastroenterol Clin Biol. 1983 Aug-Sep;7(8-9):746-9.
Because of the special physiochemical properties of ursodeoxycholate and its tauroconjugate, the effect of these two bile acids on the maximal biliary secretory rate of sulfobromophtalein was compared to that of taurocholate in the hamster. It was confirmed that taurocholate increased the maximal biliary secretory rate of the dye, while it was shown that ursodeoxycholate did not. When the bile acids were infused before sulfobromophtalein, the maximal biliary secretory rate of the dye was significantly higher under taurocholate infusion than under tauroursodeoxycholate and ursodeoxycholate infusions. Under the same conditions, the biliary bile acid output was only slightly decreased by the dye under taurocholate infusion, while it was reduced by approximately one-half under urso- and tauroursodeoxycholate infusions. These observations indicate that ursodeoxycholate is unable to increase the maximal biliary secretory rate of sulfobromophthalein (in contrast to taurocholate). It is suggested that urso- and tauroursodeoxycholate interact with sulfobromophthalein during hepatic transport and that these two bile acids may be transported by the liver by mechanisms different from those of taurocholate.
由于熊去氧胆酸盐及其牛磺结合物具有特殊的理化性质，在仓鼠中比较了这两种胆汁酸与牛磺胆酸盐对磺溴酞钠最大胆汁分泌率的影响。已证实牛磺胆酸盐可提高染料的最大胆汁分泌率，而熊去氧胆酸盐则不能。当在磺溴酞钠之前输注胆汁酸时，牛磺胆酸盐输注下染料的最大胆汁分泌率显著高于牛磺熊去氧胆酸盐和熊去氧胆酸盐输注下的分泌率。在相同条件下，牛磺胆酸盐输注时染料使胆汁胆汁酸输出仅略有下降，而在熊去氧胆酸盐和牛磺熊去氧胆酸盐输注时胆汁胆汁酸输出减少约一半。这些观察结果表明，熊去氧胆酸盐无法提高磺溴酞钠的最大胆汁分泌率（与牛磺胆酸盐相反）。提示熊去氧胆酸盐和牛磺熊去氧胆酸盐在肝脏转运过程中与磺溴酞钠相互作用，且这两种胆汁酸可能通过与牛磺胆酸盐不同的机制被肝脏转运。
