Stawis Allen N, Maennle Diane, Festuccia Moreno, Uddin Zia, Bruno Benedetto
Department of Hematology and Oncology, Webber Cancer Center, St. John Macomb-Oakland Hospital, Warren, MI 48093, USA.
Case Rep Med. 2012;2012:168785. doi: 10.1155/2012/168785. Epub 2012 Dec 25.
Extramedullary recurrence in multiple myeloma patients has been reported after both autologous and allogeneic hematopoietic cell transplantation and, more recently, after treatment with so-called new drugs with potent antimyeloma activity. Only a very few sizable reports focused on its clinical presentation and its incidence, which may be highly underestimated, and most observations are based on single patients reported from several institutions. Given the unusual sites of recurrence, diagnosis may be rather difficult and delayed treatment may play a relevant role in prognosis. Here we report a case of a myeloma patient, initially treated with an allograft, who enjoyed an eleven-year disease-free remission with very good quality of life. She eventually relapsed first with an extramedullary plasmacytoma in the breast and, two years later, with a right atrial cardiac mass.
在自体和异基因造血细胞移植后，以及最近在使用具有强效抗骨髓瘤活性的所谓新药治疗后，均有关于多发性骨髓瘤患者髓外复发的报道。仅有极少数规模较大的报告关注其临床表现和发病率，而发病率可能被严重低估，并且大多数观察结果基于多个机构报告的单个患者。鉴于复发部位不寻常，诊断可能相当困难，而治疗延迟可能对预后产生重要影响。在此，我们报告一例骨髓瘤患者，该患者最初接受了同种异体移植，享受了11年的无病缓解期，生活质量良好。她最终首先复发为乳腺髓外浆细胞瘤，两年后，又出现右心房心脏肿块。
