Amini Homayoun, Sharifi Vandad
Department of Psychiatry, Roozbeh Hospital, South Kargar Avenue, Tehran 1333795914, Iran ; Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran 1333795914, Iran.
Depress Res Treat. 2012;2012:860745. doi: 10.1155/2012/860745. Epub 2012 Dec 27.
Objectives. The aims of this study were (i) to compare Quality of Life (QOL) of patients with bipolar disorder (BD) type I to those with schizophrenia during a one-year period after hospitalization and (ii) to assess the association of different domains of QOL with severity of clinical symptoms and level of functioning in bipolar patients group. Method. A hundred and two participants were consecutively recruited before discharge from an acute hospitalization. To measure QOL as the main outcome variable, the Farsi (Persian) version of the World Health Organization's QOL Instrument Short Version (WHOQOL BREF) was used. Affective symptoms, overall functioning, and severity of mental illness were assessed as well. The assessment procedure was repeated four, eight, and 12 months after discharge. Results. No significant differences were found between patients with BD and schizophrenia on four domains of WHOQOL BREF at the baseline and the four, eight, and 12 month assessments. Within the subjects with bipolar I disorder, the most stable finding was negative association of depression severity with WHOQOL-BREF on the all four domains during repeated assessments. Conclusion. The findings suggest that persistent depressive symptoms might be the primary determinant of impaired QOL in patients with bipolar I disorder.
目的。本研究的目的是：（i）比较双相情感障碍I型（BD）患者与精神分裂症患者在住院后一年期间的生活质量（QOL）；（ii）评估双相情感障碍患者组中生活质量的不同领域与临床症状严重程度和功能水平之间的关联。方法。在急性住院出院前连续招募了102名参与者。以世界卫生组织生活质量量表简表（WHOQOL BREF）的波斯语版本作为主要结局变量来测量生活质量。同时评估情感症状、整体功能和精神疾病严重程度。出院后4个月、8个月和12个月重复评估过程。结果。在基线以及4个月、8个月和12个月评估时，BD患者和精神分裂症患者在WHOQOL BREF的四个领域中未发现显著差异。在双相I型障碍患者中，最稳定的发现是在重复评估期间，抑郁严重程度与WHOQOL - BREF在所有四个领域均呈负相关。结论。研究结果表明，持续性抑郁症状可能是双相I型障碍患者生活质量受损的主要决定因素。
