酸性pH值对抗抗原呈递的调节作用。
Regulation of antigen presentation by acidic pH.
作者信息
Jensen P E
机构信息
Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322.
出版信息
J Exp Med. 1990 May 1;171(5):1779-84. doi: 10.1084/jem.171.5.1779.
Abstract
The effect of pH on functional association of peptide antigens with APC membranes was investigated by using aldehyde-fixed B cells and class II-restricted T cell hybridomas to assess antigen/MHC complex formation. The results indicated that the rate and extent of functional peptide binding was markedly increased at pH 5.0 as compared with pH 7.3. The pH dependence of binding was preserved after pretreatment of fixed APC with pH 5.0 buffer, suggesting that pH had a direct effect on the interaction of peptide with the APC membrane. Similar results were obtained by using several peptides and I-Ad- and I-Ed-restricted T cells, indicating that pH may be of general importance in regulating the formation of functional antigen/class II MHC complexes.
摘要
通过使用醛固定的B细胞和II类限制的T细胞杂交瘤来评估抗原/MHC复合物的形成，研究了pH对肽抗原与抗原呈递细胞（APC）膜功能结合的影响。结果表明，与pH 7.3相比，在pH 5.0时功能性肽结合的速率和程度显著增加。用pH 5.0缓冲液预处理固定的APC后，结合的pH依赖性得以保留，这表明pH对肽与APC膜的相互作用有直接影响。使用几种肽以及I-Ad和I-Ed限制的T细胞也获得了类似结果，表明pH在调节功能性抗原/II类MHC复合物的形成中可能具有普遍重要性。
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