基质金属蛋白酶9-562C/T与冠心病风险的荟萃分析。
Meta-analysis of MMP9-562C/T and the risk of coronary heart disease.
作者信息
Li Junyan, Lu Hao, Tao Feng, Zhou Hua, Feng Guoyying, He Lin, Zhou Ligang
机构信息
Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Department of Endocrinology, Diabetes Research Institute, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.
出版信息
Cardiology. 2013;124(1):53-9. doi: 10.1159/000345772. Epub 2013 Jan 15.
INTRODUCTION
Previous case-control studies have suggested that the -1562C/T and R279Q polymorphisms of the matrix metalloproteinase 9 gene (MMP9) are associated with coronary heart disease (CHD). However, other studies do not confirm these relationships. The objective is to assess these relationships using meta-analysis.
METHODS
Databases, including PubMed and ScienceDirect, were searched to access the genetic association studies. Then data were extracted. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. Moreover, subgroup and sensitive analysis were performed.
RESULTS
The meta-analysis of the -1562C/T polymorphism included 12 studies with 8,336 cases and 3,984 controls. The -1562T allele was significantly associated with CHD (OR 1.25, 95% CI 1.08-1.45, p = 0.004). There was heterogeneity among the 12 studies (I2 = 61%, p = 0.003). The overall results were consistent and were not changed substantially by the removal of any data set. The meta-analysis of the R279Q polymorphism, including 6 studies with 6,983 cases and 3,282 controls, showed that the R279Q polymorphism was not associated with CHD (p = 0.16).
CONCLUSIONS
The synthesis of available evidence supports the fact that the MMP9 -1562C/T polymorphism is a risk factor for CHD.
引言
既往病例对照研究提示，基质金属蛋白酶9基因（MMP9）的-1562C/T和R279Q多态性与冠心病（CHD）相关。然而，其他研究并未证实这些关系。本研究旨在通过荟萃分析评估这些关系。
方法
检索包括PubMed和ScienceDirect在内的数据库，以获取基因关联研究。然后提取数据。计算合并比值比（OR）和95%置信区间（CI）。此外，进行亚组分析和敏感性分析。
结果
对-1562C/T多态性的荟萃分析纳入了12项研究，共8336例病例和3984例对照。-1562T等位基因与冠心病显著相关（OR 1.25，95%CI 1.08-1.45，p = 0.004）。12项研究之间存在异质性（I2 = 61%，p = 0.003）。总体结果一致，去除任何数据集后均未发生实质性变化。对R279Q多态性的荟萃分析纳入了6项研究，共6983例病例和3282例对照，结果显示R279Q多态性与冠心病无关（p = 0.16）。
结论
现有证据的综合分析支持MMP9 -1562C/T多态性是冠心病危险因素这一事实。
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