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基质金属蛋白酶-9基因-1562C>T基因多态性与中国汉族人群冠状动脉疾病：对5468名受试者的荟萃分析

Matrix metalloproteinase-9 Gene-1562C>T Gene Polymorphism and Coronary Artery Disease in the Chinese Han Population: A Meta-Analysis of 5468 Subjects.

作者信息

Li Yan-Yan, Yang Xin-Xing, Zhou Yan-Hong, Gong Ge, Geng Hong-Yu, Kim Hyun J, Zhou Chuan-Wei, Qian Yun, Wang Xiang-Ming, Wu Jun

机构信息

Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.

Department of Radiation Oncology, University of Pennsylvania Philadelphia, PA, USA.

出版信息

Front Physiol. 2016 Jun 9;7:212. doi: 10.3389/fphys.2016.00212. eCollection 2016.

DOI:10.3389/fphys.2016.00212
PMID:27375491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4899440/
Abstract

BACKGROUND

Multiple studies indicate that the matrix metalloproteinase-9 (MMP-9)-1562C>T gene polymorphism may be associated with an increased risk of coronary artery disease (CAD) in the Chinese Han population. However, a clear consensus has yet to be established.

OBJECTIVE AND METHODS

A meta-analysis of 5468 subjects from 10 separate studies was performed to explore the possible relationship between the MMP-9-1562C>T gene polymorphism and CAD within the Chinese Han population. Pooled odds ratio (ORs) for the association and the corresponding 95% confidence intervals (CIs) were evaluated by a random or fixed-effect model.

RESULTS

Our analysis confirms the association between the MMP-9-1562C>T gene polymorphism and an increased risk of CAD within the Chinese Han population under allelic (OR: 1.60, 95% CI: 1.25-2.04, P = 0.0002), recessive (OR: 3.05, 95% CI: 1.67-5.56, P = 0.0003), dominant (OR: 2.23, 95% CI: 1.49-3.35, P = 0.0001), homozygous (OR: 3.41, 95% CI: 1.87-6.23, P < 0.0001), heterozygous (OR: 2.03, 95% CI: 1.40-2.93, P = 0.0002), and additive genetic models (OR: 1.78, 95% CI: 1.33-2.39, P < 0.0001).

CONCLUSIONS

In the Chinese Han population, the MMP-9-1562C>T gene polymorphism is correlated with an increased risk of CAD. Therefore, Han Chinese carriers of the -1562T allele may be at an increased risk of CAD.

摘要

背景

多项研究表明，基质金属蛋白酶-9（MMP-9）-1562C>T基因多态性可能与中国汉族人群冠状动脉疾病（CAD）风险增加有关。然而，尚未达成明确共识。

目的与方法

对来自10项独立研究的5468名受试者进行荟萃分析，以探讨中国汉族人群中MMP-9-1562C>T基因多态性与CAD之间的可能关系。采用随机或固定效应模型评估关联的合并比值比（OR）及相应的95%置信区间（CI）。

结果

我们的分析证实，在等位基因（OR：1.60，95%CI：1.25 - 2.04，P = 0.0002）、隐性（OR：3.05，95%CI：1.67 - 5.56，P = 0.0003）、显性（OR：2.23，95%CI：1.49 - 3.35，P = 0.0001）、纯合子（OR：3.41，95%CI：1.87 - 6.23，P < 0.0001）、杂合子（OR：2.03

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e859/4899440/e2f4d30279d2/fphys-07-00212-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e859/4899440/fe7f63d4db29/fphys-07-00212-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e859/4899440/0df883798d1f/fphys-07-00212-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e859/4899440/9c09a770c4c3/fphys-07-00212-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e859/4899440/013b442254ee/fphys-07-00212-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e859/4899440/cbc37fee7444/fphys-07-00212-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e859/4899440/cb771f31943b/fphys-07-00212-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e859/4899440/e2f4d30279d2/fphys-07-00212-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e859/4899440/fe7f63d4db29/fphys-07-00212-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e859/4899440/0df883798d1f/fphys-07-00212-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e859/4899440/9c09a770c4c3/fphys-07-00212-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e859/4899440/013b442254ee/fphys-07-00212-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e859/4899440/cbc37fee7444/fphys-07-00212-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e859/4899440/cb771f31943b/fphys-07-00212-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e859/4899440/e2f4d30279d2/fphys-07-00212-g0007.jpg

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