CELFish调节mRNA衰变的方式。
CELFish ways to modulate mRNA decay.
作者信息
Vlasova-St Louis Irina, Dickson Alexa M, Bohjanen Paul R, Wilusz Carol J
机构信息
Department of Microbiology, University of Minnesota, Minneapolis, MN, USA.
出版信息
Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):695-707. doi: 10.1016/j.bbagrm.2013.01.001. Epub 2013 Jan 15.
Abstract
The CELF family of RNA-binding proteins regulates many steps of mRNA metabolism. Although their best characterized function is in pre-mRNA splice site choice, CELF family members are also powerful modulators of mRNA decay. In this review we focus on the different modes of regulation that CELF proteins employ to mediate mRNA decay by binding to GU-rich elements. After starting with an overview of the importance of CELF proteins during development and disease pathogenesis, we then review the mRNA networks and cellular pathways these proteins regulate and the mechanisms by which they influence mRNA decay. Finally, we discuss how CELF protein activity is modulated during development and in response to cellular signals. We conclude by highlighting the priorities for new experiments in this field. This article is part of a Special Issue entitled: RNA Decay mechanisms.
摘要
RNA结合蛋白CELF家族调控mRNA代谢的多个步骤。尽管其最典型的功能是在前体mRNA剪接位点选择中发挥作用，但CELF家族成员也是mRNA降解的有力调节因子。在本综述中，我们重点关注CELF蛋白通过与富含GU的元件结合来介导mRNA降解所采用的不同调控模式。在首先概述CELF蛋白在发育和疾病发病机制中的重要性之后，我们接着综述这些蛋白所调控的mRNA网络和细胞途径，以及它们影响mRNA降解的机制。最后，我们讨论CELF蛋白活性在发育过程中以及对细胞信号的响应中是如何被调节的。我们通过强调该领域新实验的重点来结束本文。本文是名为“RNA降解机制”的特刊的一部分。
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