Guo Xu-feng, Yang Wen-tao, Shi Li, Sang Yong-hua, Zhu Rong-ying, Chen Yong-bing
Department of Cardiothoracic Surgery, Second Affiliated Hospital, Soochow University, Suzhou 215004, China.
Zhonghua Yi Xue Za Zhi. 2012 Dec 4;92(45):3204-6.
To investigate the feasibility for judging the postoperative lymph node metastasis of esophagus cancer patients with pN0 stage by detecting the protein expression of metastasis-associated protein 1 (MTA1).
Immunohistochemistry was used to detect the expression of MTA1 protein in lymph node of esophageal squamous cell carcinoma (ESCC) with pN0 stage.
(1) There were no significant differences in age, gender and differentiation among the lymph node metastasis (P > 0.05), but not with pT stage (P < 0.05; χ(2) = 13.29). (2) There were no significant differences among the expression of MTA1 protein and age, gender and differentiation (P > 0.05), but not with differentiation and pT stage (P < 0.05; χ(2) = 18.61). Both stages pT1b and pT3 had higher expression of MTA1 protein than stage pT1a (P < 0.05; χ(2) = 25.54). (3) The curve of lymph node metastasis showed that the patients with no/lower MTA1 protein expression had a lower metastasis rate than those a higher MTA1 protein expression (P < 0.05; χ(2) = 16.63). (4) The results of multivariate analysis confirmed that T status and MTA1 protein over-expression were independent risk factors for pN0 stage ESCC.
Detecting MTA1 protein expression is helpful for judging the lymph node metastasis of ESCC patients with pN0 stage. And its over-expression may used as a guide in the decision-making of postoperative adjuvant therapy.
通过检测转移相关蛋白1（MTA1）的蛋白表达，探讨判断食管癌pN0期患者术后淋巴结转移的可行性。
采用免疫组织化学法检测食管鳞状细胞癌（ESCC）pN0期患者淋巴结中MTA1蛋白的表达。
（1）淋巴结转移组在年龄、性别及分化程度方面差异无统计学意义（P>0.05），但与pT分期有关（P<0.05；χ(2)=13.29）。（2）MTA1蛋白表达在年龄、性别及分化程度方面差异无统计学意义（P>0.05），但与分化程度及pT分期有关（P<0.05；χ(2)=18.61）。pT1b期和pT3期MTA1蛋白表达均高于pT1a期（P<0.05；χ(2)=25.54）。（3）淋巴结转移曲线显示，MTA1蛋白表达无/低的患者转移率低于MTA1蛋白表达高的患者（P<0.05；χ(2)=16.63）。（4）多因素分析结果证实，T分期和MTA1蛋白过表达是ESCC pN0期的独立危险因素。
检测MTA1蛋白表达有助于判断ESCC pN0期患者的淋巴结转移情况。其过表达可作为术后辅助治疗决策的指导依据。
