[MTA1基因表达与喉癌的相关性]
[Correlation between expression of the MTA1 gene and carcinomas of larynx].
作者信息
Wang Huihe, Huang Guangwu, Wei Fuyi, Mo Ligen, Kuang Guoqian
机构信息
Department of Otorhinolaryngology, the First Affiliated Hospital, Guangxi Medical University, Nanning, China.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Feb;20(3):113-5.
OBJECTIVE
To study the relation between Mta1 gene (metastasis associated gene, meta gene) and lymph node metastasis of laryngeal carcinomas.
METHOD
Reverse transcription polymerase chain reaction(RT-PCR) technique was used to detect the expression of Mta1 mRNA in 30 carcinoma of larynx tissue cases, 12 lymph nodes and 10 normal larynx tissue cases.
RESULT
The frequency of MTA1 overexpression was 100% (8/8) in primary carcinomas of larynx with metastasis but only 22.7% (5/22) in toes without metastasis (P<0.01). Expression of MTA1 was 87.5%(7/8) in lymph nodes with metastasis but only 0(0/4) in toes without metastasis(P<0.05). The frequency of Mta1 overexpression was 43.3% (13/30) in primary carcinomas of larynx.
CONCLUSION
Our data suggest that the overexpression of the MTA1 gene correlates with lymph node metastasis of carcinomas of larynx. Mta1 gene will probably become a valuable gene for judging metastasis of laryngeal carcinoma.
目的
研究Mta1基因（转移相关基因，meta基因）与喉癌淋巴结转移之间的关系。
方法
采用逆转录聚合酶链反应（RT-PCR）技术检测30例喉癌组织、12例淋巴结及10例正常喉组织中Mta1 mRNA的表达。
结果
有转移的喉原发性癌中MTA1过表达频率为100%（8/8），而无转移的为22.7%（5/22）（P<0.01）。有转移的淋巴结中MTA1表达为87.5%（7/8），无转移的为0（0/4）（P<0.05）。喉原发性癌中Mta1过表达频率为43.3%（13/30）。
结论
我们的数据表明，MTA1基因的过表达与喉癌的淋巴结转移相关。Mta1基因可能会成为判断喉癌转移的一个有价值的基因。
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