Moulds J M, Rolih C, Goldstein R, Whittington K F, Warner N B, Targoff I N, Reichlin M, Arnett F C
Department of Internal Medicine, University of Texas Medical School, Houston 77225.
J Rheumatol. 1990 Mar;17(3):331-4.
The frequencies of C4A and C4B alleles were determined in 66 adults with myositis in relation to HLA class I and II. In whites with myositis, the C4AQ0 allele occurred in 13/31 (47%) as compared to 25/101 (25%) normal controls (p = 0.08, relative risk = 2.7). Only 11/35 (31%) of black patients with myositis had a C4AQ0 allele compared to 11/55 (20%) of controls (p = NS, RR = 1.8). Thus, the MHC class III genes do not appear to be the primary genetic risk factors for myositis in adults.
