Department of Pathology, Nara Medical University School of Medicine, Nara, Japan.
Pathobiology. 2013;80(3):119-26. doi: 10.1159/000342396. Epub 2013 Jan 11.
Inflammation is an important cause of tumorigenesis in various types of malignancy. Mediators derived from inflammatory cells are associated with cancer proliferation, angiogenesis, and DNA damage. In the present study, we immunohistochemically examined the infiltration patterns of inflammatory cells in benign glands including glandular hyperplasia, and in prostatic intraepithelial neoplasia and adenocarcinoma.
Formalin-fixed, paraffin-embedded tissues were obtained from 100 patients with prostate cancer. All patients underwent radical prostatectomy. We assessed the number of infiltrating T cells (CD3(+)), B cells (CD20(+), CD79alpha(+)), and macrophages (CD68(+), CD204(+)) in benign and malignant prostate tumors.
CD68(+) macrophages infiltrated benign glands to a higher extent than those of adenocarcinoma. In contrast, the number of CD204(+) cells was higher in malignant glands than in benign glands. There was no significant difference in the number of infiltrating T cells between benign and malignant tumors; however, the number of infiltrating B cells was significantly reduced in malignant glands.
Inflammation of the prostate may act on prostate carcinomas; particularly that involving M2 macrophage infiltration may play a significant role in prostate carcinogenesis.
炎症是各种恶性肿瘤发生的重要原因。来源于炎症细胞的介质与癌症增殖、血管生成和 DNA 损伤有关。在本研究中，我们通过免疫组织化学方法检测了良性腺体（包括腺体增生）、前列腺上皮内瘤和腺癌中炎症细胞的浸润模式。
从 100 例前列腺癌患者中获得福尔马林固定、石蜡包埋的组织。所有患者均接受根治性前列腺切除术。我们评估了浸润性 T 细胞（CD3(+））、B 细胞（CD20(+）、CD79alpha(+））和巨噬细胞（CD68(+）、CD204(+））在良性和恶性前列腺肿瘤中的数量。
CD68(+)巨噬细胞浸润良性腺体的程度高于腺癌。相反，恶性腺体中 CD204(+)细胞的数量高于良性腺体。良性和恶性肿瘤之间浸润 T 细胞的数量没有显著差异；然而，恶性腺体中浸润 B 细胞的数量显著减少。
前列腺的炎症可能作用于前列腺癌；特别是 M2 巨噬细胞浸润可能在前列腺癌发生中起重要作用。
