Akashi K, Nagasawa K, Mayumi T, Yokota E, Oochi N, Kusaba T
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Rheumatol. 1990 Mar;17(3):375-9.
Two cases of refractory systemic lupus erythematosus (SLE) were successfully treated with intravenous immunoglobulins (IVIg). In Case 1, the immediate recovery from severe pancytopenia and the improvement of proteinuria were observed, following IVIg therapy in high doses (450 mg/kg) for 5 consecutive days. In Case 2, 3 courses of IVIg therapy (100 mg/kg) for 6 to 8 days resulted in a significant reduction of massive proteinuria. In both cases, the improvement of immunological variables was also seen.
两例难治性系统性红斑狼疮（SLE）患者经静脉注射免疫球蛋白（IVIg）成功治愈。病例1连续5天接受大剂量（450 mg/kg）IVIg治疗后，严重全血细胞减少症迅速恢复，蛋白尿有所改善。病例2接受3个疗程（100 mg/kg）、持续6至8天的IVIg治疗后，大量蛋白尿显著减少。两例患者的免疫指标均有所改善。
