Department of Dermatology, University of California, Davis, 3301 C Street, Sacramento, California 95816, USA.
EMBO Rep. 2013 Feb;14(2):184-90. doi: 10.1038/embor.2012.215. Epub 2013 Jan 18.
Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm(2), average field strength of ∼3 mV/mm) along the rostral migration path in adult mouse brain. Electric fields of similar strength direct migration of neuroblasts from the SVZ in culture and in brain slices. The purinergic receptor P2Y1 mediates this migration. The results indicate that naturally occurring electric currents serve as a new guidance mechanism for rostral neuronal migration.
神经前体细胞从侧脑室下区（SVZ）定向迁移的机制尚不清楚。我们在此报告称，内源性电流可作为神经前体细胞迁移的导向线索。我们发现成年小鼠大脑中沿额状迁移路径存在自然发生的电流（1.5±0.6 μA/cm2，平均场强约为 3 mV/mm）。强度相似的电场可引导 SVZ 中的神经前体细胞在体外培养和脑片中迁移。嘌呤能受体 P2Y1 介导了这种迁移。结果表明，自然发生的电流可作为一种新的导向机制，促进额状神经元的迁移。
