Kadan-Jamal Kian, Wronowski Filip, Jin Amy, Naegele Tobias E, Montes Viviana Rincón, Tao Xudong, Dominguez-Alfaro Antonio, Lee Chaeyeon, Malliaras George G
Electrical Engineering, Division Department of Engineering, University of Cambridge, Cambridge CB3 0FA, U.K.
Institute of Biological Information Processing (IBI-3) - Bioelectronics, Forschungszentrum, Leo-Brandt-Str., D-52425 Jülich, Germany.
Chem Rev. 2025 Aug 13;125(15):6874-6905. doi: 10.1021/acs.chemrev.4c00468. Epub 2025 Jul 17.
Exposure of cells to electric fields is used in applications as diverse as deep brain stimulation to treat the symptoms of Parkinson's disease, tumor-treating fields to delay the progression of hard-to-treat cancers, and electroporation to deliver genetic materials to cells. It is also used to study the fundamental properties of electrically active cells and to induce changes in cell behavior, such as the directed outgrowth of neurites, that may one day find applications in the clinic. This review discusses some of the effects elicited on cells upon exposure to electric fields, both acutely and at longer time scales, and considers the underlying mechanisms proposed. It also provides an overview of the technology used to study the effects of exposure of cell to electric fields, including the different types of metal/electrolyte interfaces and the electrode materials used in and applications. The aim is to bring together concepts from different communities to highlight similarities, identify potential synergies, and create common ground that may lead to cross-fertilization and advances in the field.
将细胞暴露于电场中有着广泛的应用，从用于治疗帕金森病症状的深部脑刺激，到用于延缓难治性癌症进展的肿瘤治疗电场，再到用于向细胞递送遗传物质的电穿孔。它还被用于研究电活性细胞的基本特性，并诱导细胞行为的变化，比如神经突的定向生长，这些变化未来有一天可能会在临床上得到应用。本文综述讨论了细胞在暴露于电场时，在急性和较长时间尺度上所引发的一些效应，并探讨了所提出的潜在机制。它还概述了用于研究细胞暴露于电场效应的技术，包括不同类型的金属/电解质界面以及在[具体应用1]和[具体应用2]中使用的电极材料。目的是整合来自不同领域的概念，以突出相似之处，识别潜在的协同作用，并创建可能导致该领域交叉融合和进步的共同基础。
