David G. Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts 02114, USA.
Ophthalmic Plast Reconstr Surg. 2013 Jul-Aug;29(4):e95-8. doi: 10.1097/IOP.0b013e31827bdadb.
Nevus comedonicus is a rare developmental abnormality of the infundibulum of the hair follicle. It is usually unilateral and commonly presents at birth or during childhood. A rare case of late-onset, bilateral nevus comedonicus of the eyelids is reported. A 79-year-old man presented with asymptomatic but disfiguring eyelid lesions noted several months earlier. On physical examination, multiple papules resembling comedones were present bilaterally in the eyelids, canthi, temple regions, and bridge of the nose. Microscopically, there were deep invaginations of the follicular canals forming focal tunnels or pseudosinus tracts with poral openings to the surface. These variably cystic structures were lined by keratinizing and nonkeratinizing squamous epithelium, contained concentric lamellae of keratin in their lumens, and some were acutely or chronically inflamed. The diagnosis of a nevus comedonicus was made. The clinical and histopathologic characteristics, pathogenesis, differential diagnosis, and management of nevus comedonicus are briefly discussed.
多发性皮脂性毛囊错构瘤是一种罕见的毛囊漏斗部发育异常。它通常为单侧性，常见于出生时或儿童期。本文报道了一例罕见的、双侧、迟发性的眼睑多发性皮脂性毛囊错构瘤。一名 79 岁男性因几个月前出现无症状但影响容貌的眼睑病变就诊。体格检查显示，双侧眼睑、眼角、颞部和鼻梁处有多个类似粉刺的丘疹。显微镜下，毛囊管有深部内陷，形成局灶性隧道或假性窦道，有孔通向表面。这些不同程度囊性结构由角化和非角化鳞状上皮组成，腔内有角质同心层，有些呈急性或慢性炎症。诊断为多发性皮脂性毛囊错构瘤。简要讨论了多发性皮脂性毛囊错构瘤的临床和组织病理学特征、发病机制、鉴别诊断和治疗。
