Ells Retina Centre, Calgary, Alberta, Canada.
Eye (Lond). 2013 Apr;27(4):525-30. doi: 10.1038/eye.2012.302. Epub 2013 Jan 18.
Current methods of treating the avascular retina with laser photocoagulation for severe retinopathy of prematurity (ROP) are not completely effective in the reduction of visual morbidity. We report a case series in which additional laser treatment, called 'posterior laser', was delivered posterior to the neovascular ridge, for eyes with severe stage 3 ROP in zone II with avascular retina posterior to the ridge.
Retrospective chart review.
Infants who underwent laser treatment, posterior to the neovascular ridge for severe ROP at the Alberta Children's Hospital, between January 2005 and October 2008.
Charts were reviewed for 18 eyes of 11 patients and collected information included demographic data, clinical examination results, and digital retinal images.
Structural and functional outcomes of treatment.
Four (22%) of 18 eyes received 'posterior laser' as primary treatment and the remainder of eyes (78%) received 'posterior laser' following previous laser photocoagulation anterior to the neovascular ridge. Mean birthweight was 688 g (552-930) and mean gestational age was 24 weeks (23-28). There were no complications because of the posterior laser treatment. In all, 16 of 18 eyes experienced rapid regression of the ridge and subsequent decrease in vascular dilation and tortuosity within 1 week. Two eyes required vitrectomy for 4A retinal detachment; however, no eyes developed stage 4B ROP.
Posterior to the ridge laser in the setting of the morphological criteria described had no increased safety concerns and resulted in rapid regression of ROP with good outcomes.
目前,对于严重早产儿视网膜病变(ROP)的无血管视网膜,采用激光光凝治疗的方法并不能完全降低视力致残率。我们报告了一系列病例,对位于 II 区严重 3 期 ROP 且血管后部有血管后部无血管的患者,在新生血管嵴后进行了额外的激光治疗,称为“后部激光”。
回顾性图表审查。
2005 年 1 月至 2008 年 10 月期间,在艾伯塔省儿童医院接受激光治疗的严重 ROP 后位于新生血管嵴后的婴儿。
对 11 例患者的 18 只眼的图表进行了回顾,并收集了人口统计学数据、临床检查结果和数字视网膜图像等信息。
治疗的结构和功能结果。
18 只眼中有 4 只(22%)作为初次治疗接受了“后部激光”,其余 14 只眼(78%)在新生血管嵴前接受了先前的激光光凝治疗后接受了“后部激光”。平均出生体重为 688 克(552-930),平均胎龄为 24 周(23-28)。没有因后部激光治疗而产生的并发症。在所有患者中,18 只眼中的 16 只眼的嵴迅速消退,随后血管扩张和扭曲度在 1 周内下降。2 只眼因 4A 视网膜脱离需要玻璃体切除术,但无一例发生 4B 期 ROP。
在描述的形态学标准下,位于嵴后的激光治疗没有增加安全性问题,并且能够迅速消退 ROP,获得良好的结果。