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免疫调节与群体感应分子 3-氧代-C12-高丝氨酸内酯：化学支架对于探针开发的重要性。

Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development.

机构信息

Department of Chemistry, The Skaggs Institute for Chemical Biology and The Worm Institute for Research and Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

出版信息

Chem Commun (Camb). 2013 Feb 21;49(15):1515-7. doi: 10.1039/c3cc38851d.

DOI:10.1039/c3cc38851d
PMID:23328974
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3566768/
Abstract

As a guide for chemical probe design, focused analogue synthetic studies were undertaken upon the lactone ring of 3-oxo-C(12)-homoserine lactone. We have concluded that hydrolytic instability of the heterocyclic ring is pivotal for its ability to modulate immune signaling and probe preparation was aligned with these findings.

摘要

作为化学探针设计的指南，我们对 3-氧代-C(12)-同型丝氨酸内酯的内酯环进行了集中的类似物合成研究。我们得出结论，杂环的水解不稳定性对于其调节免疫信号的能力至关重要，探针的制备也符合这些发现。

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本文引用的文献

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Innate immune responses to Pseudomonas aeruginosa infection.固有免疫对铜绿假单胞菌感染的应答。
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Pseudomonas signal molecule 3-oxo-C12-homoserine lactone interferes with binding of rosiglitazone to human PPARgamma.假单胞菌信号分子 3-氧代-C12-高丝氨酸内酯干扰罗格列酮与人 PPARγ 的结合。
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