Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, University of Alabama atBirmingham, Birmingham, AL, USA.
JAMA Otolaryngol Head Neck Surg. 2013 Jan;139(1):71-5. doi: 10.1001/jamaoto.2013.1111.
To analyze factors affecting 15-year surgical outcomes of choanal atresia repair.
Case series.
Tertiary care pediatric hospital.
Between April 17, 1996, and March 23, 2010, a total of 42 patients aged 3 days to 15 years underwent endoscopic or transpalatal choanal atresia repair by our pediatric otolaryngology faculty.
Reoperation and restenosis rates, with consideration of effects of mitomycin C therapy, stenting, and postoperative dilation.
Three of 42 patients were excluded because of inadequate follow-up data; the follow-up time for the remaining 39 patients averaged 6.3 years (range, 1-14.9 years). Excluding 6 patients whose initial repair was performed by other physicians, 31 of 33 patients in whom we performed initial repair had a total of 43 endoscopic surgical procedures (19 patients had unilateral procedures, and 12 patients had bilateral procedures), and the other 2 underwent bilateral transpalatal repair. Of the total 43 sides we operated on endoscopically, 9 sides (21%) required revision surgery, including excision of scar tissue or additional drilling of persistent bony stenosis. No significant difference was observed in the rate of restenosis among cases treated endoscopically with mitomycin C (22 of 43 operative sides, P = .13), with stenting (36 of 43 operative sides, P = .99), or with subsequent dilation (P = .45). When we used stents, they were usually (in 28 of 36 patients) left in place for 15 days or longer.
Our revision rate after initial endoscopic repair of choanal atresia was low and was unaffected by adjuvant mitomycin C therapy or stenting.
分析影响 15 年先天性后鼻孔闭锁修复手术结果的因素。
病例系列研究。
三级儿科医院。
1996 年 4 月 17 日至 2010 年 3 月 23 日期间,共有 42 例年龄在 3 天至 15 岁的患者接受了我们小儿耳鼻喉科医生进行的经内镜或经硬腭后鼻孔闭锁修复术。
再次手术率和再狭窄率,同时考虑丝裂霉素 C 治疗、支架置入和术后扩张的影响。
由于随访数据不足,42 例患者中有 3 例被排除;其余 39 例患者的随访时间平均为 6.3 年(范围,1-14.9 年)。排除 6 例最初修复由其他医生完成的患者,在我们进行初次修复的 33 例患者中,有 31 例共进行了 43 次经内镜手术(19 例单侧手术,12 例双侧手术),另外 2 例接受了双侧经硬腭修复。在我们经内镜手术的 43 侧中,有 9 侧(21%)需要再次手术,包括切除瘢痕组织或进一步钻除持续存在的骨狭窄。在接受丝裂霉素 C 治疗(43 例手术侧中的 22 例,P=.13)、支架置入(43 例手术侧中的 36 例,P=.99)或随后扩张(P=.45)的病例中,再狭窄率无显著差异。当我们使用支架时,通常(在 28 例患者中)将其放置 15 天或更长时间。
我们在初次经内镜修复先天性后鼻孔闭锁后的再次手术率较低,且不受辅助丝裂霉素 C 治疗或支架置入的影响。