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1
Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand.肿瘤坏死因子相关凋亡诱导配体的转录调控。
Cell Mol Life Sci. 2013 Oct;70(19):3617-29. doi: 10.1007/s00018-013-1264-x. Epub 2013 Jan 18.
2
Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.肿瘤坏死因子相关凋亡诱导配体（TRAIL）诱导的凋亡不需要受体介导的内吞作用。
J Biol Chem. 2007 Apr 27;282(17):12831-41. doi: 10.1074/jbc.M700438200. Epub 2007 Feb 27.
3
TNF-related apoptosis-inducing ligand: signalling of a 'smart' molecule.肿瘤坏死因子相关凋亡诱导配体：一种“智能”分子的信号传导
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4
Insulin promotes vascular smooth muscle cell proliferation and apoptosis via differential regulation of tumor necrosis factor-related apoptosis-inducing ligand.胰岛素通过对肿瘤坏死因子相关凋亡诱导配体的差异调节来促进血管平滑肌细胞增殖和凋亡。
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Inhibition of euchromatin histone-lysine N-methyltransferase 2 sensitizes breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through reactive oxygen species-mediated activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway activation.组蛋白赖氨酸 N-甲基转移酶 2 的抑制作用通过活性氧介导的激活转录因子 4-C/EBP 同源蛋白-死亡受体 5 途径的激活，使乳腺癌细胞对肿瘤坏死因子相关凋亡诱导配体敏感。
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TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis.肿瘤坏死因子受体相关因子2抑制肿瘤坏死因子相关凋亡诱导配体和CD95配体诱导的凋亡和坏死性凋亡。
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The three Rs along the TRAIL: resistance, re-sensitization and reactive oxygen species (ROS).沿着 TRAIL 的三个 Rs：耐药性、再敏化和活性氧物种（ROS）。
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Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation.糖基化调控肿瘤坏死因子相关凋亡诱导配体信号通路
Int J Mol Sci. 2018 Mar 2;19(3):715. doi: 10.3390/ijms19030715.

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Immunomodulatory Functions of TNF-Related Apoptosis-Inducing Ligand in Type 1 Diabetes.肿瘤坏死因子相关凋亡诱导配体在 1 型糖尿病中的免疫调节功能。
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Tumor necrosis factor‑related apoptosis‑inducing ligand is a novel transcriptional target of runt‑related transcription factor 1.肿瘤坏死因子相关凋亡诱导配体是 runt 相关转录因子 1 的一个新的转录靶标。
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Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Promotes Angiogenesis and Ischemia-Induced Neovascularization Via NADPH Oxidase 4 (NOX4) and Nitric Oxide-Dependent Mechanisms.肿瘤坏死因子相关凋亡诱导配体（TRAIL）通过NADPH氧化酶4（NOX4）和一氧化氮依赖性机制促进血管生成和缺血诱导的新生血管形成。
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8
Expression of the multidrug transporter P-glycoprotein is inversely related to that of apoptosis-associated endogenous TRAIL.多药转运蛋白P-糖蛋白的表达与凋亡相关内源性TRAIL的表达呈负相关。
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TRAIL deficiency contributes to diabetic nephropathy in fat-fed ApoE-/- mice.TRAIL 缺乏导致高脂肪饮食 ApoE-/- 小鼠发生糖尿病肾病。
PLoS One. 2014 Mar 25;9(3):e92952. doi: 10.1371/journal.pone.0092952. eCollection 2014.
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TRAIL-deficiency accelerates vascular calcification in atherosclerosis via modulation of RANKL.TRAIL 缺陷通过调节 RANKL 加速动脉粥样硬化中的血管钙化。
PLoS One. 2013 Sep 5;8(9):e74211. doi: 10.1371/journal.pone.0074211. eCollection 2013.

本文引用的文献

1
Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension.抑制肿瘤坏死因子相关凋亡诱导配体（TRAIL）可逆转实验性肺动脉高压。
J Exp Med. 2012 Oct 22;209(11):1919-35. doi: 10.1084/jem.20112716. Epub 2012 Oct 15.
2
Elevated serum TRAIL levels in scleroderma patients and its possible association with pulmonary involvement.硬皮病患者血清 TRAIL 水平升高及其与肺部受累的可能相关性。
Clin Rheumatol. 2012 Sep;31(9):1359-64. doi: 10.1007/s10067-012-2023-3. Epub 2012 Jun 23.
3
Sp1, acetylated histone-3 and p300 regulate TRAIL transcription: mechanisms of PDGF-BB-mediated VSMC proliferation and migration.Sp1、乙酰化组蛋白-3 和 p300 调节 TRAIL 转录：PDGF-BB 介导的 VSMC 增殖和迁移的机制。
J Cell Biochem. 2012 Aug;113(8):2597-606. doi: 10.1002/jcb.24135.
4
TNF-related apoptosis-inducing ligand (TRAIL) protects against diabetes and atherosclerosis in Apoe ⁻/⁻ mice.肿瘤坏死因子相关凋亡诱导配体（TRAIL）可预防 Apoe ⁻/⁻ 小鼠的糖尿病和动脉粥样硬化。
Diabetologia. 2011 Dec;54(12):3157-67. doi: 10.1007/s00125-011-2308-0. Epub 2011 Oct 1.
5
Novel transcript variants of TRAIL show different activities in activation of NF-κB and apoptosis.TRAIL 的新型转录变体在激活 NF-κB 和凋亡方面表现出不同的活性。
Life Sci. 2011 Dec 5;89(23-24):839-46. doi: 10.1016/j.lfs.2011.09.003. Epub 2011 Sep 17.
6
NFATc1 regulation of TRAIL expression in human intestinal cells.NFATc1 调控人肠细胞中 TRAIL 的表达。
PLoS One. 2011;6(5):e19882. doi: 10.1371/journal.pone.0019882. Epub 2011 May 16.
7
Association of tumor necrosis factor-related apoptosis-inducing ligand with total and cardiovascular mortality in older adults.肿瘤坏死因子相关凋亡诱导配体与老年人全因和心血管死亡率的关系。
Atherosclerosis. 2011 Apr;215(2):452-8. doi: 10.1016/j.atherosclerosis.2010.11.004. Epub 2010 Nov 11.
8
Metalloproteinase 2 cleaves in vitro recombinant TRAIL: potential implications for the decreased serum levels of TRAIL after acute myocardial infarction.金属蛋白酶 2 体外切割重组 TRAIL：对急性心肌梗死后血清 TRAIL 水平降低的潜在影响。
Atherosclerosis. 2010 Jul;211(1):333-6. doi: 10.1016/j.atherosclerosis.2010.02.024. Epub 2010 Feb 24.
9
TRAIL promotes VSMC proliferation and neointima formation in a FGF-2-, Sp1 phosphorylation-, and NFkappaB-dependent manner.TRAIL 通过依赖于 FGF-2、Sp1 磷酸化和 NFkappaB 的方式促进 VSMC 的增殖和新生内膜形成。
Circ Res. 2010 Apr 2;106(6):1061-71. doi: 10.1161/CIRCRESAHA.109.206029. Epub 2010 Feb 11.
10
TNF-related apoptosis-inducing ligand (TRAIL): a new path to anti-cancer therapies.肿瘤坏死因子相关凋亡诱导配体（TRAIL）：抗癌治疗的新途径。
Eur J Pharmacol. 2009 Dec 25;625(1-3):63-72. doi: 10.1016/j.ejphar.2009.06.066. Epub 2009 Oct 18.

肿瘤坏死因子相关凋亡诱导配体的转录调控。

Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand.

机构信息

Centre for Vascular Research, University of New South Wales, Sydney, NSW 2052, Australia.

出版信息

Cell Mol Life Sci. 2013 Oct;70(19):3617-29. doi: 10.1007/s00018-013-1264-x. Epub 2013 Jan 18.

DOI:10.1007/s00018-013-1264-x
PMID:23329170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11113472/
Abstract

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has dual functions mediating both apoptosis and survival of cells. This review focusses on the current regulatory factors that control TRAIL transcription. Here, we also highlight the role of distinct transcription factors that co-operate and regulate TRAIL in different pathological states. A better understanding of the molecular signalling pathways of TRAIL-induced cell death and survival in disease may lead to more sophisticated technologies for novel therapeutic targets.

摘要

肿瘤坏死因子相关凋亡诱导配体（TRAIL）具有双重功能，既能介导细胞凋亡，又能促进细胞存活。本综述重点介绍了目前控制 TRAIL 转录的调节因子。此外，我们还强调了不同转录因子在不同病理状态下合作和调节 TRAIL 的作用。深入了解 TRAIL 诱导细胞死亡和存活的分子信号通路，可能会为新的治疗靶点带来更复杂的技术。