肿瘤坏死因子相关凋亡诱导配体的转录调控。
Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand.
机构信息
Centre for Vascular Research, University of New South Wales, Sydney, NSW 2052, Australia.
出版信息
Cell Mol Life Sci. 2013 Oct;70(19):3617-29. doi: 10.1007/s00018-013-1264-x. Epub 2013 Jan 18.
Abstract
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has dual functions mediating both apoptosis and survival of cells. This review focusses on the current regulatory factors that control TRAIL transcription. Here, we also highlight the role of distinct transcription factors that co-operate and regulate TRAIL in different pathological states. A better understanding of the molecular signalling pathways of TRAIL-induced cell death and survival in disease may lead to more sophisticated technologies for novel therapeutic targets.
摘要
肿瘤坏死因子相关凋亡诱导配体（TRAIL）具有双重功能，既能介导细胞凋亡，又能促进细胞存活。本综述重点介绍了目前控制 TRAIL 转录的调节因子。此外，我们还强调了不同转录因子在不同病理状态下合作和调节 TRAIL 的作用。深入了解 TRAIL 诱导细胞死亡和存活的分子信号通路，可能会为新的治疗靶点带来更复杂的技术。
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