酪氨酸硫酸化修饰的血管紧张素 II 的药理活性。
Pharmacological activity of angiotensin-II modified by tyrosine sulfation.
作者信息
Hagiwara M, Ohuchi E, Hongo K, Oki M, Wada K, Morikawa T, Kobashi K
机构信息
Fuji Chemical Industries, Ltd., Toyama, Japan.
出版信息
Jpn J Pharmacol. 1990 Mar;52(3):493-5. doi: 10.1254/jjp.52.493.
An angiotensin-II analogue with a sulfated tyrosine residue was prepared by arylsulfotransferase treatment of synthetic human angiotensin-II. Its biological activities were studied in isolated smooth muscles, and its effect on blood pressure was determined. The sulfated angiotensin-II (AII-S) was about 15-30 fold less potent than angiotensin-II (AII) for ileum contraction and gallbladder contraction. The hypertensive potency of AII-S was about 30-fold less than that of AII.
通过芳基硫酸转移酶处理合成的人血管紧张素 II 制备了一种带有硫酸化酪氨酸残基的血管紧张素 II 类似物。在离体平滑肌中研究了其生物学活性，并测定了其对血压的影响。硫酸化血管紧张素 II（AII-S）在回肠收缩和胆囊收缩方面的效力比血管紧张素 II（AII）低约 15 - 30 倍。AII-S 的升压效力比 AII 低约 30 倍。
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