Sollich V, Schuster R, Thal W, Köhler E, Walther H
Klinik für Kinderheilkunde, Medizinischen Akademie, Magdeburg.
Kinderarztl Prax. 1990 Jan;58(1):45-8.
Experiences in 50 patients show that Theophyllin retard Oranienburg (280 mg theophylline) could be used as an effective bronchospasmolytic drug on conditions of mono- and combination-therapy. Advantages of this preparation are improvement of the compliance and an undisturbed night-sleep in patients. However an optimum dosage is hardly maintained in children by the present dose of a single tablet of 280 theophylline content. The effectiveness in therapy of childhood asthma could be improved by stronger sustained release effect and different doses of tablets.
50例患者的经验表明，奥雷宁堡缓释茶碱（含280毫克茶碱）可作为单药治疗和联合治疗情况下有效的支气管解痉药物。该制剂的优点是提高了患者的依从性并使其夜间睡眠不受干扰。然而，按照目前每片含280毫克茶碱的剂量，儿童很难维持最佳剂量。更强的缓释效果和不同剂量的片剂可能会提高儿童哮喘治疗的有效性。
