de Blic J, Scheinmann P, Benoist M R, Ruff F, Paupe J
Arch Fr Pediatr. 1983 Feb;40(2):123-7.
Continuous sustained-release theophylline therapy was used in 61 children with severe asthma, aged 5 to 16 years. Mean treatment duration was 5 months 8 days (range: 8 days-16 months). The necessary dosage to obtain correct blood theophylline levels was 18 +/- 3.6 mg/kg/day (range: 10-31 mg/kg/day). The adaptation of the doses to blood theophylline levels and regular check-ups confirmed intrapatient variability and the dose-dependent disposition of theophylline. In 35 of the 42 children (82%) who were observed for more than 3 months, theophylline induced a decrease of the frequency of the attacks and a better attendance to school. Nine times out of 30, oral steroid administration or sustained-release cosyntropin injections could be stopped and in 15, the dosages could be decreased by at least 50%. Evaluations of pulmonary function, performed several times in 12 children, showed that theophylline induces significant bronchodilatation, mostly of the large bronchi.
61名5至16岁的重度哮喘儿童接受了持续缓释茶碱治疗。平均治疗时长为5个月零8天（范围：8天至16个月）。获得正确血药茶碱水平所需剂量为18±3.6毫克/千克/天（范围：10至31毫克/千克/天）。根据血药茶碱水平调整剂量并定期检查证实了患者体内茶碱的变异性及剂量依赖性处置。在42名接受观察超过3个月的儿童中，有35名（82%）茶碱减少了发作频率，上学出勤率也更高。30次中有9次，口服类固醇给药或缓释促肾上腺皮质激素注射可以停用，15次中，剂量至少可减少50%。对12名儿童进行了多次肺功能评估，结果显示茶碱可引起显著的支气管扩张，主要是大支气管。
